Clinical significance of accumulation of chylomicron remnants and its functional analysis by selective isolation
| Project/Area Number |
15K01713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Osaka University |
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Principal Investigator |
Masuda Daisaku 大阪大学, 医学系研究科, 特任助教 (20568753)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | レムナント / apoB-48 / 脳塞栓 / 動脈硬化 / 糖尿病 / リポ蛋白 / DPP4阻害薬 / 耐糖能異常 |
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| Outline of Final Research Achievements |
Apo B-48 concentration was positively correlated with concentrations of TG, RemL-C, oxidative stress markers in cases of annual health checkup with no abnormality and significantly low in patients with cardiogenic cerebral embolism, it was very useful for evaluating risk status with accumulating remnants. The apoB-48 level was significantly higher in patients with impaired glucose tolerance and diabetes mellitus than in cases without them, and it was increased after the glucose load and suppressed by administration of DPP4 inhibitor. Chylomicron remnants selectively separated by anti-apoB-48 monoclonal antibody have various sizes, have not only many apoproteins but also proteins related to inflammation such as complements and PON-1 and can induce macrophage foam cell formation. This study revealed the utility of the apo B-48 measurement in the risk assessment or evaluating treatment effects and the physiological activity of chylomicron remnant.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] A Novel Selective PPARα Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice2018
Author(s)
Masami Sairyo, Takuya Kobayashi, Daisaku Masuda, Koutaro Kanno, Yinghong Zhu, Takeshi Okada, Masahiro Koseki, Tohru Ohama, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 25
Issue: 2
Pages: 142-152
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Open Access
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[Presentation] Evaluation, Analysis and Treatment of the Residual Risk of Atherosclerotic Cardiovascular Diseases, the Accumulation of Chylomicron Remnants2017
Author(s)
Daisaku Masuda, Takuya Kobayashi, Kohtaro Kanno, Masami Sairyou, Takeshi Okada, Tohru Ohama, Masahiro Koseki, Makoto Nishida, Yasushi Sakata and Shizuya Yamashita
Organizer
第81回日本循環器学会学術集会
Place of Presentation
金沢市
Year and Date
2017-03-17
Related Report
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[Presentation] Proteomic analysis and comparison of selectively-isolated apolipoprotein B48- and B100-containing lipoproteins in human serum2016
Author(s)
Takuya Kobayashi, Daisaku Masuda, Masami Sairyo, Takeshi Okada, Ryota Kawase, Kazuhiro Nakatani, Masahiro Koseki, Tohru Ohama, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
Organizer
76th American Diabetes Association
Place of Presentation
New Orleans, LA, America
Year and Date
2016-06-10
Related Report
Int'l Joint Research
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