| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Vascular endothelial cells have important roles in homeostasis of cardiovascular system. Aims of this study were to observe gut microbiota in early-stage atherosclerosis animal model, to search food-derived compounds those induce endothelium-dependent vasodilation, and to investigate effects of these compounds on gut microbiota.
Intima-thickened aorta and decrease of endothelium-dependent vasodilation were observed in high fat diet (HFD)-fed C57BL/6 mice By phylum-specific quantitative polymerase chain reaction (qPCR) for monitoring gut microbiota, HFD-fed mice had higher Firmicutes bacteria than normal diet-fed mice, but did not change Bacteroidetes bacteria. And we found that some food-derived polyphenols had activity of endothelium-dependent vasodilation, but couldn't check any effect of those on gut microbiota.
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