Dose skeletal muscle derived metabolite affects exercise induced reduction of intrahepatic fat.

• Project/Area Number: 15K01724
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Nagasaki
• Principal Investigator: Tobina Takuro 長崎県立大学, 看護栄養学部, 准教授 (60509678)
• Co-Investigator(Kenkyū-buntansha): 田中 宏暁 福岡大学, スポーツ科学部, 教授 (00078544) ; 吉村 英一 熊本県立大学, 環境共生学部, 准教授 (70613214)
• Co-Investigator(Renkei-kenkyūsha): YOSHIMURA Eiichi 熊本県立大学, 環境共生学部, 准教授 (70613214)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 運動療法 / 乳酸閾値 / 脂肪肝 / β-アミノイソ酪酸 / βアミノイソ酪酸 / メタボライト / 血液分析

Outline of Final Research Achievements

Beta-aminoisobutyric acid (BAIBA), a product of valine degradation, is a known myokine. Serum BAIBA activates beta-oxidation in hepatocytes. This study investigated whether moderate intensity exercise training increase serum BAIBA and it affects intrahepatic fat. After 3 months exercise training intervention, there were positive relationship between the changes of thigh cross sectional area, intrahepatic fat, and BAIBA. The association was found in subjects with higher intrahepatic fat, however negative correlation was found in subjects with lower intrahepatic fat.
This study demonstrated that blood BAIBA concentration may influence of exercise induced intrahepatic fat alternation. In addition, the relationship might difference depend on the initial intrahepatic fat level.

Research Products

• [Presentation] Influence of energy restriction and moderate intensity exercise training on serum beta aminoisobutylic acid (2017)
  • Author(s): Ishihara M, Tobina T, Shiose K, Yoshimura E, Kumahara H, Ayabe M, Matsuda T, Kiyonaga A, Higaki Y, Tanaka H.
  • Organizer: 22th European college of sport science
  • Place of Presentation: Essen（ドイツ）
  • Year and Date: 2017-07-05
  • Int'l Joint Research
• [Presentation] Influence of Energy Restriction and Moderate Intensity Exercise Training on Serum Beta-Aminoisobutyric acid (2017)
  • Author(s): Ishihara M, Tobina T, Shiose K, Yoshimura E, Kumahara H, Ayabe M, Matsuda T, Kiyonaga A, Higaki Y, Tanaka Hi
  • Organizer: 22nd annual congress of the European College of Sports Science
  • Int'l Joint Research
• [Presentation] βアミノイソ酪酸定量を目的とした試料・保存方法の検討 (2016)
  • Author(s): 石原麻由, 永山千尋, 飛奈卓郎
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 盛岡市民文化ホール（岩手県・盛岡市）
  • Year and Date: 2016-09-23
• [Presentation] Energy restriction attenuates exercise induced muscular mitochondrial biogenesis (2015)
  • Author(s): Takuro Tobina, Keisuke Shiose, Eiichi Yoshimura, Hideaki Kumahara, Makoto Ayabe, Takuro Matsuda, Akira Kiyonaga, Yasuki Higaki, Hiroaki Tanaka
  • Organizer: 17th International Biochemistry of Exercise Conference
  • Place of Presentation: Sao paulo
  • Year and Date: 2015-09-07
  • Int'l Joint Research