| Project/Area Number |
15K01740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Osaka Women's Junior College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋本 貢士 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (30396642)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAZAKI Tomomi (00218439)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DNAメチル化 / 脂肪酸 / 魚油 / エピゲノム / PPAR / 生活習慣病 / エピジェネティクス / n-3系脂肪酸 / 飽和脂肪酸 / DOHaD / 糖尿病 / 肥満 |
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| Outline of Final Research Achievements |
Maternal fatty acids intake from dietary oil, during pregnancy to lactation, may affect the onset of lifestyle diseases in the next generation. To clarify the mechanism, maternal mice were feed high fat lard diet or high fat fish oil diet from pregnancy to lactation, and the liver of offspring were analyzed. The gene expression of neonatal liver showed difference, which accompanied changes of DNA methylation by maternal diet. Especially, large changes were observed in fatty acid metabolism related genes of maternal high fat fish oil diet group. Therefore, maternal dietary fatty acids could control the gene expression trough DNA methylation on specific metabolic pathway in neonatal liver, where organ is immature.
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