A cohort study on the relationship between social development and oxytocin dynamics.
| Project/Area Number |
15K01753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | University of Fukui |
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Principal Investigator |
Fujisawa Takashi 福井大学, 子どものこころの発達研究センター, 特命講師 (90434894)
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 大輔 金沢大学, 子どものこころの発達研究センター, 特任准教授 (30390701)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMODA AKEMI 福井大学, 子どものこころの発達研究センター, 教授 (80244135)
KOSAKA HIROTAKA 福井大学, 子どものこころの発達研究センター, 教授 (70401966)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | オキシトシン / 社会行動 / 唾液 / 視線 / 脳画像 / ホルモン / 環境 / 社会性 / 発達 |
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| Outline of Final Research Achievements |
In this study, we investigated the effect of oxytocin on social development in childhood and adolescence. We measured them for children and adolescents and investigated the association between the relationship between social behavior and the physiological status for children and adolescents. As results, in the study on early childhood, we observed a negative association between age and both attention toward social cues and salivary oxytocin levels. In the study on adolescence, we investigated the relationship between DNA methylation of oxytocin receptor and its impact on the brain structures of atypical developmental children with difficulties in interpersonal relationships. As results, we observed negative correlations of gray matter volume in the frontal cortex with the methylation, and group with difficulties showed significantly reduced the volume than healthy controls. These results suggest that oxytocin dynamics on critical periods play important role for social development.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Increased anterior pelvic angle characterizes the gait of children with attention deficit/hyperactivity disorder (ADHD)2017
Author(s)
Naruse H, Fujisawa TX, Yatsuga C, Kubota M, Matsuo H, Takiguchi, S, Shimada S, Imai Y, Hiratani M, Kosaka H, Tomoda A.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: A 24-week randomized clinical trial.2016
Author(s)
Kosaka H, Okamoto Y, Munesue T, Yamasue H, Inohara K, Fujioka T, Anme T, Orisaka M, Ishitobi M, Jung M, Fujisawa TX, Tanaka S, Arai S, Asano M, Saito DN, Sadato N, Tomoda A, Omori M, Sato M, Okazawa H, Higashida H, Wada Y.
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Journal Title
Trans Psychiatry
Volume: 6
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults.2016
Author(s)
Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
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Journal Title
Molecular Autism
Volume: 7
Issue: 1
Pages: 19-19
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effectiveness in cognitive function of oral tipepidine administration for children with attention deficit/hyperactivity disorder: A 4-week, open-label clinical study.2015
Author(s)
Tomoda A, Takiguchi S, Fujisawa TX, Yatsuga C, Kumazaki H, Fujioka T, Suzuki H, Matsuzaki H, Kosaka H, Tanaka S.
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 69
Issue: 10
Pages: 658-659
DOI
Related Report
Peer Reviewed
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[Journal Article] Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: A functional MRI Study.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Okamoto Y, Shimada K, Koizumi M, Kumazaki H, Jung M, Kosaka H, Hiratani M, Ohshima Y, Teicher, MH, Tomoda A.
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Journal Title
British Journal of Psychiatry Open
Volume: 1
Issue: 2
Pages: 121-128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 選択性緘黙の併存が自閉スペクトラム症の社会的情報への注目にあたえる影響2017
Author(s)
藤岡徹, 新井清義, 水野賀史, 滝口慎一郎, 藤澤隆史, 土屋賢治, 片山泰一, 松﨑秀夫, 友田明美, 平谷美智夫, 小坂浩隆.
Organizer
第58回日本児童青年精神医学会総会
Related Report
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[Presentation] The neural effects of intranasal oxytocin administration in reactive attachment disorder.2016
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Shimada K, Nishikawa S, Takada S, Okamoto Y, Mizuno Y, Kosaka H, Tomoda A.
Organizer
The 58th Annual Meeting of the Japanese Society of Child Neurology
Place of Presentation
Tokyo, Japan
Year and Date
2016-06-03
Related Report
Int'l Joint Research
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[Presentation] Low striatal activity during reward perception caused by childhood adversity.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Kumazaki H, Koizumi M, Shimada K, Okamoto Y, Jung M, Kosaka H, Tomoda A.
Organizer
第57回日本小児神経学会
Place of Presentation
大阪
Year and Date
2015-05-29
Related Report
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[Presentation] Which parameters differ in the gait of children with ADHD?2015
Author(s)
Naruse H, Yatsuga C, Fujisawa TX, Kumazaki H, Takiguchi S, Mizushima S, Matsuo H, Kubota M, Shimada S, Kosaka H, Tomoda A.
Organizer
The 5th World congress on ADHD
Place of Presentation
Glasgow, UK
Year and Date
2015-05-17
Related Report
Int'l Joint Research
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[Presentation] Reward sensitivity dysfunction in children and adolescents with reactive attachment disorder.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Okamoto Y, Shimada K, Kumazaki H, Koizumi M, Jung M, Kosaka H, Tomoda A.
Organizer
The 13th Asian and Oceania Congress of Child Neurology (2015 AOCCN)
Place of Presentation
Taipei, Taiwan
Year and Date
2015-05-15
Related Report
Int'l Joint Research
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[Presentation] Can Robotic Interaction Improve Nonverbal Communication and Social Anxiety of Children with Autism Spectrum Disorders?2015
Author(s)
Kumazaki H, Yoshikawa Y, Matsumoto Y, Mizushima S, Fujisawa T.X, Kosaka H, Tomoda A, Nemoto S, Nakano M, Miyao M, Maeda T, Ishiguro H, Muramatsu M, Mimura M.
Organizer
International Meeting for Autism Research (IMFAR)
Place of Presentation
Salt Lake City, USA
Year and Date
2015-05-14
Related Report
Int'l Joint Research
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