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The effect of oxytocin and cortisol on maternal-child relationships and child mental development

Research Project

Project/Area Number 15K01755
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Childhood science (childhood environment science)
Research InstitutionTottori University

Principal Investigator

Kurozawa Youichi  鳥取大学, 医学部, 教授 (50161790)

Co-Investigator(Kenkyū-buntansha) 大西 一成  山梨大学, 大学院総合研究部, 特任准教授 (50596278)
松下 博昭  岡山大学, 医歯薬学総合研究科, 助教 (60732394)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords母子保健 / オキシトシン / コルチゾール / 養育行動 / 子宮内膜症 / 不安障害 / 子育て / 母子関係形成 / 自閉症 / ストレス
Outline of Final Research Achievements

Oxytocin is a peptide-hormone related with parental behavior. However, it is unknown that how oxytocin affects mother-child relationships. To elucidate this, we analyzed the relationships between JECS study and plasma oxytocin concentration during pregnancy. The oxytocin concentration of women with medical history of endometriosis or anxiety disorder is significantly lower than normal women. Women with high oxytocin concentration have a tendency to reduce the anxiety to parental behavior. Our study suggest that medical history affects oxytocin concentration during pregnancy and oxytocin affects parental behavior.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Oxytocin inhibits corticosterone-induced apoptosis in primary hippocampal neurons.2018

    • Author(s)
      Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsui
    • Journal Title

      Neuroscience

      Volume: - Pages: 383-389

    • DOI

      10.1016/j.neuroscience.2018.03.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] オキシトシンは海馬神経細胞におけるコルチコステロン誘導性の樹状突起の萎縮を抑制する2017

    • Author(s)
      佐藤亜紀,ヘインミンラット,松下博昭,道上宏之,西木禎一,松井秀樹
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      静岡県浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] オキシトシン・コルチゾールの母子関係形成と子どもへ与える影響2017

    • Author(s)
      大西一成
    • Organizer
      第31回日本助産学会学術集会
    • Place of Presentation
      徳島県徳島市
    • Year and Date
      2017-01-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The relation between medical history and oxytocin concentration during gestation period in Japanese pregnant women2017

    • Author(s)
      Toshio Masumoto, Kazunari Onishi, Hiroaki Matsushita, Hiroki Amano, Shinji Otani, Hideki Matsui, Youichi Kurozawa
    • Organizer
      The 21st International Epidemiological Association WorldCongress of Epidemiology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 既往歴の産前・産後血中オキシトシン濃度へ与える影響2017

    • Author(s)
      増本年男、大西一成、松下博昭、天野宏紀、 大谷眞二、松井秀喜、黒沢洋一
    • Organizer
      第60回鳥取県公衆衛生学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] xytocin prevents corticosterone-induced dendritic atrophy in mouse hippocampal neurons.2017

    • Author(s)
      Hein Min Latt, Aki Sato, Yuuri Koga, Hiroaki Matsushita, Hiroyuki Michiue, Atsushi Fujimura, Teiichi Nishiki, Hideki Matsui
    • Organizer
      第69回日本生理学会中国・四国地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Exploration of question items connected with the neglect in the Japan environment and Children’s Study - From temporary data of Yamanashi2016

    • Author(s)
      Kazunari Onishi, Aya Sakakihara, Miri Sato, Sonoko Mizorogi, Ryouji Shinohara, Kohta Suzuki, Zentaro Yamagata
    • Organizer
      5th Conference on Prenatal Programming and Toxicity
    • Place of Presentation
      福岡県北九州市
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neuroprotective effect of oxytocin on corticosterone-induced apoptosis in mouse hippocampal neurons.2016

    • Author(s)
      Hein Min Latt, Miku Morino, Yuuri Koga, Hiroaki Matsushita, Hiroyuki Michiue, Teiichi Nishiki, Hideki Matsui
    • Organizer
      第68回日本生理学会中国四国地方会
    • Place of Presentation
      岡山県岡山市
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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