Cancer prevention effect of calorie restriction on radiation induded B-cell leukemia
| Project/Area Number |
15K01790
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Childhood science (childhood environment science)
|
|---|
| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
|---|
Principal Investigator |
Shang Yi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 研究員(任常) (50533189)
|
|---|
| Research Collaborator |
DAINO Kazuhiro
MORIOKA Takamitsu
KAKINUMA Shizuko
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | カロリー制限 |
|---|
| Outline of Final Research Achievements |
It is well known that children are more susceptible to carcinogenic effects of radiation as compared with adults. So that there is a critical need to make efforts for assessing risk and developing prevention strategies for radiation-induced cancer after childhood exposure. Using mouse model, earlier we reported that adult-onset calorie restriction (CR) reduced the risk of late-occurring lymphomas but not early-onset lymphomas. To investigate the mechanism of CR, we established immunohistochemical staining method to diagnose lymphomas into 4 subtypes. Using next generation sequencing method, we analyzed whole exosome sequence of B-cell leukemia samples, found special mutations in this mouse model.
|
Report
(4 results)
Research Products
(7 results)
