| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is well known that children are more susceptible to carcinogenic effects of radiation as compared with adults. So that there is a critical need to make efforts for assessing risk and developing prevention strategies for radiation-induced cancer after childhood exposure. Using mouse model, earlier we reported that adult-onset calorie restriction (CR) reduced the risk of late-occurring lymphomas but not early-onset lymphomas. To investigate the mechanism of CR, we established immunohistochemical staining method to diagnose lymphomas into 4 subtypes. Using next generation sequencing method, we analyzed whole exosome sequence of B-cell leukemia samples, found special mutations in this mouse model.
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