| Project/Area Number |
15K01805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Chitose Institute of Science and Technology |
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Principal Investigator |
Kawano Keiichi 千歳科学技術大学, 理工学部, 特別研究員 (10136492)
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| Co-Investigator(Renkei-kenkyūsha) |
Karthaus Olaf 千歳科学技術大学, 理工学部, 教授 (80261353)
KIMURA Hiromi 千歳科学技術大学, 理工学部, 教授 (00574857)
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| Research Collaborator |
KOBAYASHI Shota
AIZAWA Tomoyasu
MIZUGUCHI Mineyuki
YOKOYAMA Takeshi
NABESHIMA Yuko
HIRATA Masato
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | オステオカルシン / 多臓器相関 / 糖代謝 / 骨形成 / 立体構造解析 / NMR / X線結晶解析 / 活性型 / ハイドロキシアパタイト / 吸着 / ＮＭＲ / Ｘ線結晶解析 / 安定同位体標識 |
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| Outline of Final Research Achievements |
Osteocalcin (OC), which was known as a protein useful for the formation of bone, has been found to be a hormone with various activities such as control of sugar metabolism, lipid metabolism, production of testosterone. Stimulation of bones is known as a key of health and rejuvenation. Despite its importance, a little of molecular mechanisms are known. Since OC is activated in an acidic environment, the three-dimensional structures of OC in acidic state were examined by CD, NMR and X-ray crystallography. As a result, it was revealed that OC is able to maintain structure and hormonal activity even in acidic environment.
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