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Size-Controlled and Biocompatible Paramagnetic Nanoparticles for Dual Photoacoustic and MR Imaging

Research Project

Project/Area Number 15K01819
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical biology
Research InstitutionKyoto University

Principal Investigator

KONDO TERUYUKI  京都大学, 工学研究科, 教授 (20211914)

Co-Investigator(Kenkyū-buntansha) 木村 祐  京都大学, 健康長寿社会の総合医療開発ユニット, 特定准教授 (90566027)
山田 久嗣  徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 講師 (80512764)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords光超音波イメージング / 磁気共鳴イメージング / 常磁性金属酸化物 / ナノ粒子 / 分子プローブ / 造影剤 / 抗癌剤 / セラノスティック / HER2 完全長抗体 / ゼラチン / 常磁性金属 / マンガン酸化物 / 糖 / 生体適合性
Outline of Final Research Achievements

One of the most rapidly developing and exciting applications of nanotechnology in biomedical research is the development of biocompatible nanoparticles (NPs) for use in multiple powerful and highly complementary imaging modalities.Gd-based inorganic nanoparticles such as Gd2O3 have recently been investigated as potential positive contrast agents in magnetic resonance imaging (MRI). However, our main goal is to synthesize and isolate new size-controlled and biocompatible paramagnetic metal oxide NPs, Gd2O3 and MnO, as a bimodal contrast agent for use in photoacoustic (PA) and MR imaging through the fusion of inorganic NPs and organic materials.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016 2015 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 8 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Tracking the Oxygen Status in the Cell Nucleus with a Hoechst-Tagged Phosphorescent Ruthenium Complex2018

    • Author(s)
      Hara Daiki、Umehara Yui、Son Aoi、Asahi Wataru、Misu Sotaro、Kurihara Ryohsuke、Kondo Teruyuki、Tanabe Kazuhito
    • Journal Title

      ChemBioChem

      Volume: 19 Issue: 9 Pages: 956-962

    • DOI

      10.1002/cbic.201700685

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ruthenium- and Rhodium-Catalyzed Ring-Opening Coupling Reactions of Cyclopropenones with Alkenes or Alkynes2018

    • Author(s)
      Kondo Teruyuki、Taniguchi Ryosuke、Kimura Yu
    • Journal Title

      Synlett

      Volume: 29 Issue: 06 Pages: 717-722

    • DOI

      10.1055/s-0037-1609339

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymeric 1H MRI Probes for Visualizing Tumor In Vivo2017

    • Author(s)
      Kondo Teruyuki、Kimura Yu、Yamada Hisatsugu、Aoyama Yasuhiro
    • Journal Title

      Chem. Rec.

      Volume: 17 Issue: 6 Pages: 555-568

    • DOI

      10.1002/tcr.201600144

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dioxetane formation and chemiluminescent emission upon the combination of a vinylphenol derivative with naphthalene endoperoxide2017

    • Author(s)
      Umehara Y, Son A, Kondo T, Tanabe K.
    • Journal Title

      RSC Advances

      Volume: 7 Issue: 16 Pages: 9472-9475

    • DOI

      10.1039/c6ra28079j

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ruthenium- and rhodium-catalyzed strain-driven cleavage and reconstruction of the C-C bond2016

    • Author(s)
      Kondo T.
    • Journal Title

      European Journal of Organic Chemistry

      Volume: - Issue: 7 Pages: 1232-1242

    • DOI

      10.1002/ejoc.201501291

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Yb(OTf)3-catalyzed synthesis of 2-substituted 4(3H)-quinazolinones via cleavage of a carbon-carbon bond2016

    • Author(s)
      Yoshimura T, Naito S, Yuanjun D, Son A, Kimura Y, Toshimitsu A, Kondo, T.
    • Journal Title

      Heterocycles

      Volume: 96 Issue: 2 Pages: 816-823

    • DOI

      10.3987/com-15-s(t)59

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 13C/15N-Enriched l-Dopa as a Triple-Resonance NMR Probe to Monitor Neurotransmitter Dopamine in the Brain and Liver Extracts of Mice2015

    • Author(s)
      Hisatsugu Yamada, Tetsuro Kameda, Yu Kimura, Hirohiko Imai, Tetsuya Matsuda, Shinsuke Sando, Akio Toshimitsu, Yasuhiro Aoyama, Teruyuki Kondo
    • Journal Title

      Chemistry Open

      Volume: e-Pub Issue: 2 Pages: 125-128

    • DOI

      10.1002/open.201500196

    • NAID

      120005844253

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic resonance imaging of tumor with a self-traceable polymer conjugated with an antibody fragment2015

    • Author(s)
      Yamada H, Hasegawa Y, Suzuki Y, Imai H, Matsuda T, Kimura Y, Toshimitsu A, Aoyama Y, Kondo T.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 13 Pages: 2675-2678

    • DOI

      10.1016/j.bmcl.2015.04.072

    • NAID

      120005672621

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of chiral dendrimer-triamine-coordinated Gd-MRI contrast agents evaluated by in vivo MRI and estimated by in vitro QCM2015

    • Author(s)
      Miyake Y, Ishikawa S, Kimura Y, Son A, Imai H, Matsuda T, Yamada H, Toshimitsu A, Kondo T.
    • Journal Title

      Sensors

      Volume: 15 Issue: 12 Pages: 31973-31986

    • DOI

      10.3390/s151229900

    • NAID

      120007141563

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and functional evaluation of chiral dendrimer-triaminecoordinated Gd complexes with polyaminoalcohol end groups as highly sensitive MRI contrast agents2015

    • Author(s)
      Miyake Y, Kimura Y, Orito N, Imai H, Matsuda T, Toshimitsu A, Kondo T.
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 26-27 Pages: 4438-4444

    • DOI

      10.1016/j.tet.2015.04.050

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer2015

    • Author(s)
      Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo
    • Journal Title

      Journal of the American Chemical Society

      Volume: 137 Issue: 2 Pages: 799-806

    • DOI

      10.1021/ja510479v

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Innovative Techno-Hub for Integrated Medical Bio-Imaging2017

    • Author(s)
      Teruyuki KONDO
    • Organizer
      Week26 International and Innovation Week (Université de Bordeaux)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Novel Molecular Probes for MRI and the Next-Generation PAI2017

    • Author(s)
      Teruyuki KONDO
    • Organizer
      The 3rd Bordeaux-Kyoto Symposium: Creating the science and technology innovation in the cutting-edge
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Novel MRI Contrast Agents for Macrophage Imaging Enables Risk Evaluation of Unruptured Cerebral Aneurysm2017

    • Author(s)
      Teruyuki KONDO
    • Organizer
      The 3rd Bordeaux-Kyoto Symposium: Creating the science and technology innovation in the cutting-edge
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rare Earth Metal Triflates-Catalyzed Synthesis of Benzoazoles via Cleavage of a C-C Bond2017

    • Author(s)
      Teruyuki KONDO
    • Organizer
      Nordic/Kyoto OMCOS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 躍進する化学 ~最先端材料の創製から医療応用まで~: 双極性ポリマーを基盤とする次世代イメージングプローブの創製2017

    • Author(s)
      近藤 輝幸
    • Organizer
      「京都アカデミアフォーラム」 in 丸の内 京大テックフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 双極性ポリマー PMPC を基盤とする高次生体イメージングプローブの創製2016

    • Author(s)
      近藤輝幸
    • Organizer
      青山学院大学化学・生命科学科・講演会(理工学会共催)
    • Place of Presentation
      青山学院大学相模原キャンパス
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] MPC を基盤とする高度機能性イメージングプローブの創製2016

    • Author(s)
      近藤輝幸
    • Organizer
      京都大学テックコネクト新技術説明会 2016
    • Place of Presentation
      京都大学大学院工学研究科イノベーションプラザ
    • Year and Date
      2016-03-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 有機合成化学を基盤とする生体イメージングのための革新的分子プローブの開発2016

    • Author(s)
      近藤輝幸
    • Organizer
      第2回京都コモンズワークショップ-京都大学工学研究科化学系基礎研究(有機合成化学)ワークショップ-
    • Place of Presentation
      京都市成長産業創造センター(ACT Kyoto)
    • Year and Date
      2016-02-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] がんの分子イメージング2015

    • Author(s)
      近藤輝幸, 木村祐, 三宅由花.
    • Total Pages
      269
    • Publisher
      (株)化学同人
    • Related Report
      2015 Research-status Report
  • [Remarks] https://www.abe.ehcc.kyoto-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] http://www.abe.ehcc.kyoto-u.ac.jp/

    • Related Report
      2016 Research-status Report
  • [Remarks] 京都大学 学際融合教育研究推進センター 先端医工学研究ユニット 分子プローブ合成分野 近藤研究室

    • URL

      http://www.probe.abe.kyoto-u.ac.jp/

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] Polymer and contrast agent for photoacoustic imaging2016

    • Inventor(s)
      Kondo T. et al.
    • Industrial Property Rights Holder
      Canon Inc.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-28
    • Related Report
      2016 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] POLYMER, AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING, INCLUDING THE POLYMER2015

    • Inventor(s)
      Kondo T. et al.
    • Industrial Property Rights Holder
      Kondo T. et al.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-10-09
    • Related Report
      2015 Research-status Report
    • Overseas

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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