| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The synthesis of continuously branched core hexasaccharide produced by gram-negative bacteria was successfully accomplished by using block coupling of the oligosaccharide donor with a 2-4 linked Kdo acceptor. For the construction of 3,4-branched heptose structure, the use of toluene was found to be effective solvent from a 4-O-substituted heptose with a heptose donor. The 4,5-branched tri-, tetra-, and pentasaccharide were also synthesized with complete stereoselectivity by the same manner. The oligosaccharide-biotin conjugate and sugar coated magnetic nanoparticle were synthesized. The human IgG selected by using the synthetic carbohydrate coated magnetic nanoparticle was found to recognized Salmonella minesota Re-LPS.
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