| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Matriglycan strongly interacts with laminine to form muscular tissue. In this study, the oligosaccharide which composes matriglycan was chemically synthesized and we clarified the facile structure. In addition, we regio- and stereoselectively synthesized xylosyl ribitolphosphate which locates at the reducing side of matriglycan at the first time. NMR data of the chemically synthesized compound was compatible with those of natural product. The xylosyl ribitolphosphate will be a primer of the enzymatic glycan elongation to form bypass-like glycans as therapeutic agent for muscular dystrophy.
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