Development of cancer cell-targeting off/on type fluorescence probes based on biological molecules.
Project/Area Number |
15K01827
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical biology
|
Research Institution | Nagahama Institute of Bio-Science and Technology |
Principal Investigator |
Kawai Yasushi 長浜バイオ大学, バイオサイエンス学部, 教授 (20240830)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 蛍光プローブ / 酵素活性検出 / プテリン / がん細胞 / 分子イメージング |
Outline of Final Research Achievements |
Folate receptor is a target for novel chemotherapeutic agents because of its overexpression on the surface of many epithelial cancer cells. In this research, diaminopteridine as a recognized moiety of folate receptor was developed as a multifunctional fluorescent probe. This probe can control off-on switching of fluorescence by enzyme activity such as glutathion-S-transferase specifically expressed in cancer cell, and also can oxidatively damage a G-rich portion of DNA oligomer by irradiating UV light in its fluorescence on state.
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Report
(4 results)
Research Products
(7 results)