| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Folate receptor is a target for novel chemotherapeutic agents because of its overexpression on the surface of many epithelial cancer cells. In this research, diaminopteridine as a recognized moiety of folate receptor was developed as a multifunctional fluorescent probe. This probe can control off-on switching of fluorescence by enzyme activity such as glutathion-S-transferase specifically expressed in cancer cell, and also can oxidatively damage a G-rich portion of DNA oligomer by irradiating UV light in its fluorescence on state.
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