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Biological mechanisms underlying positive emotion on stress vulnerability in adolescent rat

Research Project

Project/Area Number 15K01838
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionFoundation for Advancement of International Science

Principal Investigator

HORI MIYO  公益財団法人国際科学振興財団, バイオ研究所, 専任研究員 (90399329)

Co-Investigator(Kenkyū-buntansha) 村上 和雄  公益財団法人国際科学振興財団, バイオ研究所, 主席研究員 (70110517)
一谷 幸男  筑波大学, 人間系, 教授 (80176289)
山田 一夫  筑波大学, 人間系, 准教授 (30282312)
大西 淳之  東京家政大学, 家政学部, 教授 (40261276)
Co-Investigator(Renkei-kenkyūsha) SAKAMOTO SHIGEKO  (公財)国際科学振興財団, バイオ研究所, 専任研究員 (60419869)
SENBA EMIKO  大阪行岡医療大学, 医療学部, 教授 (00135691)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsTickling / 幼若期ストレス / 社会隔離飼育 / 快情動 / 扁桃体 / 恐怖条件づけ / 遺伝子発現 / 高架式十字迷路 / 強制水泳 / 社会隔離ストレス / 幼若期
Outline of Final Research Achievements

Neural mechanizes underling positive emotion were investigated using behavioral analysis such as open field, elevated plus maze, forced swimming and fear conditioning, and biochemical indices in post-weaning rats. Tickling stimulation, resembles the rough-and-tumble play behavior in rats, were recovered several behavior changes that were caused by electric foot-shock and/or social isolation in the open field, in the elevated plus maze, in the forced swimming and in the fear conditioning. On the other hand, social isolation altered amygdala in the adolescent rat, and many genes and microRNA were up- and down-regulated. We found that tickling stimulation could restore these stress-induced genes and microRNA expression changes in amygdala. In conclusion, positive emotion may alter directly and/or indirectly neuronal circuitry including amygdala through the play in adolescence.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Distinct Transcriptional and Metabolic Profiles Associated with Empathy in Buddhist Priests: A Pilot Study2017

    • Author(s)
      Ohnishi J, Ayuzawa S, Nakamura S, Sakamoto S, Hori M, Sasaoka T, Takimoto-Ohnishi E, Tanatsugu M, Murakami K.
    • Journal Title

      Human Genomics

      Volume: 11 Issue: 1 Pages: 3-16

    • DOI

      10.1186/s40246-017-0117-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 病気を笑いで癒やす2017

    • Author(s)
      堀美代,村上和雄
    • Journal Title

      体育の科学

      Volume: 67 Pages: 551-554

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 笑いや感動が遺伝子をONにする2015

    • Author(s)
      村上和雄、堀美代
    • Journal Title

      癒しの環境Japan Society of Healing Environment

      Volume: 20 Pages: 23-28

    • Related Report
      2015 Research-status Report
  • [Presentation] Dopamine D1 and D2/3 receptor antagonism effect on tickling induced 50-kHz ultrasonic vocalizations in the adolescent rats2017

    • Author(s)
      M Hori, R Shimoju, J Ohnishi, K Murakami, M Kurosawa
    • Organizer
      SOCIETY FOR NEUROSCIENCE 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene expression profiling: effects of tickling on restraint stress in the adolescent rats.2017

    • Author(s)
      Hori M, Ohnishi J, Yamada K, Sakamoto S, Ichitani Y, Murakami K.
    • Organizer
      行動2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dopamine receptor antagonism effect on tickling induced 50-kHz USVs in the adolescent rats.2016

    • Author(s)
      Hori M, et.al.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学,札幌
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Tickling during adolescence overcomes stress vulnerability induced by isolated rearing.2015

    • Author(s)
      Hori M, Yamada K, Ohnishi J, Furuie H, Murakami K, Ichitani Y.
    • Organizer
      日本動物心理学会第75回大会
    • Place of Presentation
      日本女子大学 目白キャンパス, 東京
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Remarks] Neuroscience 2017

    • URL

      http://mind-gene.com/blog/news/1149/

    • Related Report
      2017 Annual Research Report
  • [Remarks] Neuroscience 2017

    • URL

      https://www.facebook.com/mindgene.murakami

    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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