| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, we proposed a novel method to control neural response characteristics in specific brain regions using closed-loop electrophysiology. First, we analyzed spectro-temporal receptive field (STRF) in each subfield and layer in the rodent auditory cortex (AC) by using flavoprotein fluorescence imaging and local field potential recording. Then, we revealed that STRF of each neuron in freely moving mouse AC were dynamically changed between two different behavioral contexts. Based on the obtained results, we inserted multichannel silicon electrodes which cover various auditory fields and layers, and we succeeded to construct a real-time closed-loop system that can stimulate through arbitrary channels according to the estimated STRFs from the neural recordings.
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