• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Unvealing a functional implication of beta oscillations in the motor cortex

Research Project

Project/Area Number 15K01854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionTohoku University

Principal Investigator

Watanabe Hidenori  東北大学, 医学系研究科, 助教 (00407686)

Co-Investigator(Renkei-kenkyūsha) MUSHIAKE Hajime  東北大学, 大学院医学系研究科, 教授 (80219849)
TAKAHASHI Kazutaka  東北大学, 大学院医学系研究科, 講師 (90797945)
KAJITA Yuki  東北大学, 大学院医学系研究科, 助手 (00791849)
Nambu Atsushi  生理学研究所, システム脳科学研究領域, 教授 (80180553)
CHIKEN Satomi  生理学研究所, システム脳科学研究領域, 助教 (30396262)
SANO Hiromi  生理学研究所, システム脳科学研究領域, 助教 (00363755)
KOBAYASHI Kenta  生理学研究所, ウィルスベクター開発室, 准教授 (70315662)
HOSAKA Ryosuke  福岡大学, 理学部, 助教 (80569210)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsベータ波 / オプトジェネティス / サル / 皮質運動野 / オプトジェネティクス / ベータ脳波 / 大脳皮質運動野 / 位相
Outline of Final Research Achievements

Beta oscillation is generally known as neural oscillation related to movements with a frequency range between 12 and 30 Hz. It, however, remains unclear what type of information is carried in beta oscillation. Optogenetics is capable of manipulating neural activity by targeting specific cells at millisecond precision. The proposed research will investigate if modulation of beta oscillations induced optogenetically can cause any changes in arm movement of macaque monkeys, thereby elucidating causality between beta oscillation and motor output. Our preliminary results showed a high level of expression of light-gated ion channel (ChR2) in the primary motor cortex in monkeys, and arm-movements were induced by optical stimuli. Thus, our results will be a basis to use optogenetic approaches to macaque monkeys in order to enhance our understanding of motor cortical circuits and their relation to behaviors.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] University of Chicago(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Chicago(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Phase locking of β oscillation in electrocorticography (ECoG) in the monkey motor cortex at the onset of EMGs and 3D reaching movements.2015

    • Author(s)
      Hidenori Watanabe, Kazutaka Takahashi, Tadashi Isa
    • Journal Title

      Conference proceedings - IEEE engineering in medicine and biology society

      Volume: 1 Pages: 55-58

    • DOI

      10.1109/embc.2015.7318299

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Phase Locking of β Oscillation in the Monkey Motor Cortical Areas with Chronic 3D Electrode Arrays.2017

    • Author(s)
      Hidenori Watanabe, Kazutaka Takahashi, Hajime Mushiake.
    • Organizer
      National Institute for Physiological Sciences, Research Meeting at Tohoku. (生理学研究所研究会@東北 「脳の階層的理解を目指して」)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phase Locking and Current Source Density Profiles of β Oscillation in the Monkey Motor Cortical Areas with Chronic 3D Electrode Arrays.2017

    • Author(s)
      Hidenori Watanabe, Hajime Mushiake, Kazutaka Takahashi.
    • Organizer
      International symposium Neural Oscillation Conference 2017, 'Problems of Consciousness and Neuropsychiatric Disorders as Network Diseases'.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased LFP theta power in primate motor areas reflects memorization of Movement2017

    • Author(s)
      Ryosuke Hosaka, Hidenori Watanabe, Toshi Nakajima, Hajime Mushiake
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      ACT CITY Hamamatsu, Shizuoka, Japan
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 霊長類(サル)における多点電極記録とその解析2017

    • Author(s)
      渡辺秀典
    • Organizer
      機械学習・情報理論・神経科学ワークショップ
    • Place of Presentation
      知識科学棟, 北陸先端科学技術大学院大学, 石川県, 日本
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 渡辺秀典 大脳皮質運動野におけるベータ脳波の位相ロック2016

    • Author(s)
      Hidenori Watanabe
    • Organizer
      第5 回超異分野学会
    • Place of Presentation
      日本橋ライフサイエンスハブ, 日本橋, 東京, 日本.
    • Year and Date
      2016-03-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Amplitude and phase of beta oscillation in electrocorticography in the monkey motor cortex at the onset of reaching movements.2015

    • Author(s)
      Hidenori Watanabe
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting.
    • Place of Presentation
      Life Science Project Research Building, Tohoku University Katahira Campus, Sendai, Japan
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Phase locking of β oscillation in electrocorticography (ECoG) in the monkey motor cortex at the onset of EMGs and 3D reaching movements2015

    • Author(s)
      Hidenori Watanabe, Kazutaka Takahashi, Tadashi Isa
    • Organizer
      The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      MiCo - Milano Conference Center - Milan, Italy
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Antipsychotic drugs for schizophrenia prevented increasing of high-gamma activities in the primary motor cortex of monkeys2015

    • Author(s)
      Hidenori Watanabe, Hidetoshi Komatsu, Yusuke Kondo, Yukio Nishimura
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe Convention Center, Port Island, Kobe, Japan
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] ベータ脳波の機能的意味を探る

    • URL

      http://www.neurophysiology.med.tohoku.ac.jp/image/watanabehm/Functional%20roles%20of%20beta%20oscillations-j.jpg

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-05-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi