• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Traumatic memory provoked by odor in rats' fear conditioning and maternal separation

Research Project

Project/Area Number 15K04180
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionUniversity of Tsukuba

Principal Investigator

YAMADA Kazuo  筑波大学, 人間系, 准教授 (30282312)

Co-Investigator(Kenkyū-buntansha) 一谷 幸男  筑波大学, 人間系, 教授 (80176289)
Co-Investigator(Renkei-kenkyūsha) AYABE Saho  筑波大学, 人間系, 教授 (40323232)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsラット / ニオイ刺激 / トラウマ記憶 / 恐怖条件づけ / 母子分離 / 養育行動 / 新生仔期母仔分離 / 情動行動 / 条件性恐怖反応 / ニオイ / 性差
Outline of Final Research Achievements

We examined effects of odors on the acquisition and the extinction of traumatic memories using two PTSD animal models: fear conditioning and maternal separation paradigms. Our data showed that 1. the extinction of fear responses associated with contextual stimulus could not generalize those associated with odor stimulus, 2. only male rats preferred the odor stimulus that they experiences during maternal separation. 3. the fact that mothers took care of male pups more than females’ could cause the sex differences in their preference to odor stimulus related to traumatic memories.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 6 results) Presentation (13 results) (of which Int'l Joint Research: 7 results) Remarks (2 results)

  • [Journal Article] Differential requirements of hippocampal de novo protein and mRNA synthesis in two long term spatial memory tests: spontaneous place recognition and delay-interposed radial maze performance in rats.2017

    • Author(s)
      Ozawa, T., Yamada, K. & Ichitani, Y.
    • Journal Title

      PLOS ONE

      Volume: 12(2) Issue: 2 Pages: e0171629-e0171629

    • DOI

      10.1371/journal.pone.0171629

    • NAID

      120007134985

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The relationship between fear extinction and resilience to drug-dependence in rats2017

    • Author(s)
      Masaharu Ueno, Kazuo Yamada, Yukio Ichitani
    • Journal Title

      Neuroscience Research

      Volume: 印刷中 Pages: 37-42

    • DOI

      10.1016/j.neures.2017.03.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of hippocampal NMDA receptors in encoding and consolidation, but not retrieval, processes of spontaneous object location memory in rats2017

    • Author(s)
      Yamada, K., Arai, M., Suenaga, T. & Ichitani, Y.
    • Journal Title

      Behavioural Brain Research

      Volume: 331 Pages: 14-19

    • DOI

      10.1016/j.bbr.2017.05.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic NMDA receptor blockade in early postnatal period, but not in adulthood, impairs methamphetamine-induced conditioned place preference in rats.2016

    • Author(s)
      Furuie, H., Yamada, K. & Ichitani, Y.
    • Journal Title

      Behavioural Brain Research

      Volume: 301 Pages: 253-257

    • DOI

      10.1016/j.bbr.2015.12.044

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hippocampal NMDA receptors are involved in rats’ spontaneous object recognition only under high memory load condition.2015

    • Author(s)
      Sugita, M., Yamada, K., Iguchi, N. & Ichitani, Y.
    • Journal Title

      Brain Research

      Volume: 1624 Pages: 370-379

    • DOI

      10.1016/j.bbr.2016.03.048

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hippocampal AP5 treatment impairs both spatial working and reference memory in radial maze performance in rats.2015

    • Author(s)
      Yamada, K., Shimizu, M., Kawabe, K. & Ichitani, Y.
    • Journal Title

      European Journal of Pharmacology

      Volume: in press Pages: 137-141

    • DOI

      10.1016/j.ejphar.2015.03.080

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Latent inhibition in rats neonatally treated chronically with MK-801: Differential effects on conditioned taste aversion and conditioned emotional response.2015

    • Author(s)
      Niikura,R., Nozawa, T., Yamada,K., Kato, K. & Ichitani,Y.
    • Journal Title

      Behavioural Brain Research

      Volume: 283 Pages: 102-107

    • DOI

      10.1016/j.bbr.2015.01.029

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The odor associated with maternal memories reduces anxiety in adult rats.2017

    • Author(s)
      Mochizuki-Kawai, H., Ayabe-kanamura, S., Ichitani, Y. & Yamada, K.
    • Organizer
      Association for Chemoreception Sciences, 39th Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of the rat hippocampal NMDA and AMPA receptors in temporal order memory in radial maze.2017

    • Author(s)
      Sugita, M., Yamada, K. & Ichitani, Y.
    • Organizer
      International Behavioral Neuroscience Scoiety, Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social enrichment enhances rats’ memory span of social, but not object, recognition.2017

    • Author(s)
      Toyoshima, M., Yamada, K., Sugita, M. & Ichitani, Y.
    • Organizer
      Society for Neuroscience, 47th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spontaneous novel object recognition, object location recognition, and temporal order discrimination in rats neonatally treated chronically with MK-801.2017

    • Author(s)
      Hatakeyama, T., Furuie, H., Yamada, K. & Ichitani, Y.
    • Organizer
      Society for Neuroscience, 47th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Individual ability of fear extinction predicts their resilience to drug addiction in rats.2016

    • Author(s)
      Ueno, M., Yamada, K. & Ichitani, Y.
    • Organizer
      International Congress of Psychology
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sex differences in maternal care determine effects of infant odor memory on anxiety-related behavior in adult rats.2016

    • Author(s)
      Yamada, K., Ishikawa, H., Osato, Y., Ayabe-Kanamura, S. & Ichitani, Y.
    • Organizer
      Association for Chemoreception Sciences, 38th Annual meeting
    • Place of Presentation
      Fort Myers, FL, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of chronic postnatal NMDA receptor blockade on latent inhibition in preadolescent rats.2016

    • Author(s)
      Aiman, I.M., Niikura, R., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Individual ability for fear extinction is independent from the depressive-like behaviors in rats.2016

    • Author(s)
      Ueno, M., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of inter-presentation interval in the sample phase and retention interval on the temporal order memory using spontaneous object recognition paradaigm in rats.2016

    • Author(s)
      Hatakeyama, T., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第76回大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Hippocampal NMDA receptors are involved in rats’ spontaneous object recognition only under high memory load condition.2015

    • Author(s)
      Yamada, K., Sugita, M. & Ichitani, Y.
    • Organizer
      Society for Neuroscience, 45th Annual Meeting
    • Place of Presentation
      Chicago, IL USA
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Scopolamine administered before retrieval diminishes retrieval-induced forgetting in spontaneous object recognition in rats.2015

    • Author(s)
      Ichikawa, A., Ichitani, Y. & Yamada, K.
    • Organizer
      日本動物心理学会第75回大会
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Role of hippocampal NMDA receptors in the retrieval of spontaneous object recognition memory in rats.2015

    • Author(s)
      Takano, E., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第75回大会
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of number of items on the temporal order memory in spontaneous object recognition in rats.2015

    • Author(s)
      Hatakeyama, T., Yamada, K. & Ichitani, Y.
    • Organizer
      日本動物心理学会第75回大会
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Remarks] 筑波大学大学院 人間総合科学研究科 感性認知脳科学専攻 行動神経科学分野 一谷・山田グループ

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2017 Annual Research Report 2015 Research-status Report
  • [Remarks] 筑波大学人間総合科学研究科 感性認知脳科学専攻 行動神経科学分野 一谷・山田研究室

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi