Traumatic memory provoked by odor in rats' fear conditioning and maternal separation

• Project/Area Number: 15K04180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental psychology
• Research Institution: University of Tsukuba
• Principal Investigator: YAMADA Kazuo 筑波大学, 人間系, 准教授 (30282312)
• Co-Investigator(Kenkyū-buntansha): 一谷 幸男 筑波大学, 人間系, 教授 (80176289)
• Co-Investigator(Renkei-kenkyūsha): AYABE Saho 筑波大学, 人間系, 教授 (40323232)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ラット / ニオイ刺激 / トラウマ記憶 / 恐怖条件づけ / 母子分離 / 養育行動 / 新生仔期母仔分離 / 情動行動 / 条件性恐怖反応 / ニオイ / 性差

Outline of Final Research Achievements

We examined effects of odors on the acquisition and the extinction of traumatic memories using two PTSD animal models: fear conditioning and maternal separation paradigms. Our data showed that 1. the extinction of fear responses associated with contextual stimulus could not generalize those associated with odor stimulus, 2. only male rats preferred the odor stimulus that they experiences during maternal separation. 3. the fact that mothers took care of male pups more than females’ could cause the sex differences in their preference to odor stimulus related to traumatic memories.

Research Products

• [Journal Article] Differential requirements of hippocampal de novo protein and mRNA synthesis in two long term spatial memory tests: spontaneous place recognition and delay-interposed radial maze performance in rats. (2017)
  • Author(s): Ozawa, T., Yamada, K. & Ichitani, Y.
  • Journal Title: PLOS ONE Volume: 12(2) Issue: 2 Pages: e0171629-e0171629
  • DOI: 10.1371/journal.pone.0171629
  • NAID: 120007134985
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The relationship between fear extinction and resilience to drug-dependence in rats (2017)
  • Author(s): Masaharu Ueno, Kazuo Yamada, Yukio Ichitani
  • Journal Title: Neuroscience Research Volume: 印刷中 Pages: 37-42
  • DOI: 10.1016/j.neures.2017.03.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of hippocampal NMDA receptors in encoding and consolidation, but not retrieval, processes of spontaneous object location memory in rats (2017)
  • Author(s): Yamada, K., Arai, M., Suenaga, T. & Ichitani, Y.
  • Journal Title: Behavioural Brain Research Volume: 331 Pages: 14-19
  • DOI: 10.1016/j.bbr.2017.05.006
  • Peer Reviewed
• [Journal Article] Chronic NMDA receptor blockade in early postnatal period, but not in adulthood, impairs methamphetamine-induced conditioned place preference in rats. (2016)
  • Author(s): Furuie, H., Yamada, K. & Ichitani, Y.
  • Journal Title: Behavioural Brain Research Volume: 301 Pages: 253-257
  • DOI: 10.1016/j.bbr.2015.12.044
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hippocampal NMDA receptors are involved in rats’ spontaneous object recognition only under high memory load condition. (2015)
  • Author(s): Sugita, M., Yamada, K., Iguchi, N. & Ichitani, Y.
  • Journal Title: Brain Research Volume: 1624 Pages: 370-379
  • DOI: 10.1016/j.bbr.2016.03.048
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hippocampal AP5 treatment impairs both spatial working and reference memory in radial maze performance in rats. (2015)
  • Author(s): Yamada, K., Shimizu, M., Kawabe, K. & Ichitani, Y.
  • Journal Title: European Journal of Pharmacology Volume: in press Pages: 137-141
  • DOI: 10.1016/j.ejphar.2015.03.080
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Latent inhibition in rats neonatally treated chronically with MK-801: Differential effects on conditioned taste aversion and conditioned emotional response. (2015)
  • Author(s): Niikura,R., Nozawa, T., Yamada,K., Kato, K. & Ichitani,Y.
  • Journal Title: Behavioural Brain Research Volume: 283 Pages: 102-107
  • DOI: 10.1016/j.bbr.2015.01.029
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The odor associated with maternal memories reduces anxiety in adult rats. (2017)
  • Author(s): Mochizuki-Kawai, H., Ayabe-kanamura, S., Ichitani, Y. & Yamada, K.
  • Organizer: Association for Chemoreception Sciences, 39th Annual meeting
  • Int'l Joint Research
• [Presentation] Involvement of the rat hippocampal NMDA and AMPA receptors in temporal order memory in radial maze. (2017)
  • Author(s): Sugita, M., Yamada, K. & Ichitani, Y.
  • Organizer: International Behavioral Neuroscience Scoiety, Annual Meeting
  • Int'l Joint Research
• [Presentation] Social enrichment enhances rats’ memory span of social, but not object, recognition. (2017)
  • Author(s): Toyoshima, M., Yamada, K., Sugita, M. & Ichitani, Y.
  • Organizer: Society for Neuroscience, 47th Annual Meeting
  • Int'l Joint Research
• [Presentation] Spontaneous novel object recognition, object location recognition, and temporal order discrimination in rats neonatally treated chronically with MK-801. (2017)
  • Author(s): Hatakeyama, T., Furuie, H., Yamada, K. & Ichitani, Y.
  • Organizer: Society for Neuroscience, 47th Annual Meeting
  • Int'l Joint Research
• [Presentation] Individual ability of fear extinction predicts their resilience to drug addiction in rats. (2016)
  • Author(s): Ueno, M., Yamada, K. & Ichitani, Y.
  • Organizer: International Congress of Psychology
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Int'l Joint Research
• [Presentation] Sex differences in maternal care determine effects of infant odor memory on anxiety-related behavior in adult rats. (2016)
  • Author(s): Yamada, K., Ishikawa, H., Osato, Y., Ayabe-Kanamura, S. & Ichitani, Y.
  • Organizer: Association for Chemoreception Sciences, 38th Annual meeting
  • Place of Presentation: Fort Myers, FL, USA
  • Int'l Joint Research
• [Presentation] Effects of chronic postnatal NMDA receptor blockade on latent inhibition in preadolescent rats. (2016)
  • Author(s): Aiman, I.M., Niikura, R., Yamada, K. & Ichitani, Y.
  • Organizer: 日本動物心理学会第76回大会
  • Place of Presentation: 北海道大学（北海道札幌市）
• [Presentation] Individual ability for fear extinction is independent from the depressive-like behaviors in rats. (2016)
  • Author(s): Ueno, M., Yamada, K. & Ichitani, Y.
  • Organizer: 日本動物心理学会第76回大会
  • Place of Presentation: 北海道大学（北海道札幌市）
• [Presentation] Effects of inter-presentation interval in the sample phase and retention interval on the temporal order memory using spontaneous object recognition paradaigm in rats. (2016)
  • Author(s): Hatakeyama, T., Yamada, K. & Ichitani, Y.
  • Organizer: 日本動物心理学会第76回大会
  • Place of Presentation: 北海道大学（北海道札幌市）
• [Presentation] Hippocampal NMDA receptors are involved in rats’ spontaneous object recognition only under high memory load condition. (2015)
  • Author(s): Yamada, K., Sugita, M. & Ichitani, Y.
  • Organizer: Society for Neuroscience, 45th Annual Meeting
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] Scopolamine administered before retrieval diminishes retrieval-induced forgetting in spontaneous object recognition in rats. (2015)
  • Author(s): Ichikawa, A., Ichitani, Y. & Yamada, K.
  • Organizer: 日本動物心理学会第75回大会
  • Place of Presentation: 日本女子大学（東京都文京区）
  • Year and Date: 2015-09-11
• [Presentation] Role of hippocampal NMDA receptors in the retrieval of spontaneous object recognition memory in rats. (2015)
  • Author(s): Takano, E., Yamada, K. & Ichitani, Y.
  • Organizer: 日本動物心理学会第75回大会
  • Place of Presentation: 日本女子大学（東京都文京区）
  • Year and Date: 2015-09-11
• [Presentation] Effects of number of items on the temporal order memory in spontaneous object recognition in rats. (2015)
  • Author(s): Hatakeyama, T., Yamada, K. & Ichitani, Y.
  • Organizer: 日本動物心理学会第75回大会
  • Place of Presentation: 日本女子大学（東京都文京区）
  • Year and Date: 2015-09-11
• [Remarks] 筑波大学大学院 人間総合科学研究科 感性認知脳科学専攻 行動神経科学分野 一谷・山田グループ
  • URL: http://www.kansei.tsukuba.ac.jp/~ichitanilab/
• [Remarks] 筑波大学人間総合科学研究科 感性認知脳科学専攻 行動神経科学分野 一谷・山田研究室
  • URL: http://www.kansei.tsukuba.ac.jp/~ichitanilab/