Traumatic memory provoked by odor in rats' fear conditioning and maternal separation
| Project/Area Number |
15K04180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
YAMADA Kazuo 筑波大学, 人間系, 准教授 (30282312)
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| Co-Investigator(Kenkyū-buntansha) |
一谷 幸男 筑波大学, 人間系, 教授 (80176289)
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| Co-Investigator(Renkei-kenkyūsha) |
AYABE Saho 筑波大学, 人間系, 教授 (40323232)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ラット / ニオイ刺激 / トラウマ記憶 / 恐怖条件づけ / 母子分離 / 養育行動 / 新生仔期母仔分離 / 情動行動 / 条件性恐怖反応 / ニオイ / 性差 |
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| Outline of Final Research Achievements |
We examined effects of odors on the acquisition and the extinction of traumatic memories using two PTSD animal models: fear conditioning and maternal separation paradigms. Our data showed that 1. the extinction of fear responses associated with contextual stimulus could not generalize those associated with odor stimulus, 2. only male rats preferred the odor stimulus that they experiences during maternal separation. 3. the fact that mothers took care of male pups more than females’ could cause the sex differences in their preference to odor stimulus related to traumatic memories.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Sex differences in maternal care determine effects of infant odor memory on anxiety-related behavior in adult rats.2016
Author(s)
Yamada, K., Ishikawa, H., Osato, Y., Ayabe-Kanamura, S. & Ichitani, Y.
Organizer
Association for Chemoreception Sciences, 38th Annual meeting
Place of Presentation
Fort Myers, FL, USA
Related Report
Int'l Joint Research
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