Detection of residual functions in persons with dementia
| Project/Area Number |
15K04191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Chuo University |
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Principal Investigator |
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| Research Collaborator |
Piguet Olivier
Kawai Yoshinari
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 認知症 / 機能亢進 / 残存機能 / 芸術 / 介護 / 周辺症状 / BPSD / 視線 / 介護者 / 緩徐進行性失語症 / 意味性認知症 / アイトラッカー / 意志決定支援 / 前頭側頭型認知症（FTD） / アルツハイマー病（AD） / 原発性進行性失語症（PPA） / 神経心理学 / 眼球運動 / 機能向上 / サヴァン / 感覚過敏 / 主観 |
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| Outline of Final Research Achievements |
This study aimed to systematically identify behavioural changes in three types of dementia: Alzheimer’s disease (AD) , behavioral-variant frontotemporal dementia (bvFTD) and primary progressive aphasia(PPA). Caregivers of patients with dementia participated in the study. Caregivers rated the presence and frequency of positive and negative behavior changes after the onset of dementia using the newly developed scales namely Hypersensory and Social/Emotional Scale (HSS) questionnaire, focusing on three domains: sensory processing, cognitive skills, and social/emotional processing. Differences across scores and ratios of increased and decreased behaviors were analyzed. After disease onset, significant changes in the sensory processing domain were observed across disease severity levels. In addition to the questionnaire study, the eye tracking system was used to collect residual function of severely demented subjects and confirmed its potential benefit.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでの認知症についての基礎研究の多くは、認知機能の低下に焦点が当てられてきたが、本研究は認知症における残存機能や亢進する機能にも焦点を当てている点を特徴としている。調査の結果、認知症の多くの患者において感覚の過敏性を示すことが確認されたが、このことを周囲が理解することによって、認知症における周辺症状（BPSD）の低減に寄与することと思われる。また、自発的な表出が困難な認知症においても、視線を通じて残存機能の把握ができる可能性が見いだされたことから、このような理解が進むことによって、将来的には、認知症当事者の見直しにもつながることと思われる。
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Report
(5 results)
Research Products
(71 results)
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[Journal Article] Operative Strategies during Awake Surgery Affect Deterioration of Paresis a Month after Surgery for Brain Lesions in the Primary Motor Area2016
Author(s)
Shinoura, N., Midorikawa, A., Yamada, R., Hiromitsu, K., Itoi, C., Saito, S. & Yagi, K.
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Journal Title
Journal of Neurological Surgery Part A: Central European Neurosurgery.
Volume: -
Issue: 04
Pages: 368-373
DOI
Related Report
Peer Reviewed
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[Journal Article] All Is Not Lost: Positive Behaviors in Alzheimer’s Disease and Behavioral-Variant Frontotemporal Dementia with Disease Severity2016
Author(s)
Midorikawa, A., Leyton, C. E., Foxe, D., Landin-Romero, R., Hodges, J. R. & Piguet, O.
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Journal Title
Journal of Alzheimer's Disease
Volume: 54
Issue: 2
Pages: 549-558
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The modified six elements test: earlier diagnosis of the correlation between motor and executive dysfunction in Parkinson’s disease without dementia2015
Author(s)
Murakami, H , Owan Y, Oguchi T, Nomoto S, Shozawa H, Kubota S, Mori Y, Mizuma K, Futamura A, Kobayakawa M, Kezuka M, Midorikawa A, Miller M, Kawamura M
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Journal Title
Neurology and Clinical Neuroscience
Volume: 3
Issue: 6
Pages: 209-214
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] A. Contribution of the prefrontal and parietal regions to time estimation and temporal control: A study of patients with a brain tumor before and after surgery2018
Author(s)
Shigemune, Y., Saito, S., Hiromitsu, K., Hamamoto, K., Shinoura, N., Yamada, R., & Midorikawa, .
Organizer
Cognitive Neuroscience Society
Related Report
Int'l Joint Research
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[Presentation] Measuring the Sense of Self in Brain-damaged Patients2017
Author(s)
Hiromitsu K., Asai, T., Saito, S., Shigemune, Y., Hamamoto, K., Shinoura, N., Yamada, R., & Midorikawa A
Organizer
Science of the Self
Related Report
Int'l Joint Research
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[Presentation] The disconnecting syndromes and temporal order judgment2017
Author(s)
Futamura, A., Kuroda, T., Shiromaru, A., Honma, M., Masaoka, Y., Midorikawa, A., Yamamoto, S., Kitazawa, S., Kawamura, M., & Ono, K.
Organizer
The XXIII World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] Characterization of ‘positive’ behaviours in primary progressive aphasias2017
Author(s)
Midorikawa, A., Kumfor, F., Leyton, C., Foxe, D., Landin-Romero, R., Hodges, J., Piguet, O.
Organizer
XXIII World Congress of Neurology
Related Report
Int'l Joint Research
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[Presentation] All is not lost: positive behaviors in Alzheimer’s disease and behavioral-variant frontotemporal dementia with disease severity.2016
Author(s)
Midorikawa, A., Leyton, C.E., Foxe, D., Landin-Romero, R., Hodges J.R. & Piguet, O.
Organizer
10th International Conference on Frontotemporal Dementias
Place of Presentation
Munich, Germany
Year and Date
2016-08-31
Related Report
Int'l Joint Research
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[Presentation] Autobiographical age awareness disturbance (AAAD) syndrome in autoimmune limbic encephalitis (Thematic Session: Axes in our mental time: is there any unique time axis for mankind?).2016
Author(s)
Kawamura, M., Kuroda, T., Futamura, A., Sugimoto, A., Midorikawa, A. & Honma, M.
Organizer
31st International Congress of Psychology (ICP2016)
Place of Presentation
Yokohama, Japan
Year and Date
2016-07-24
Related Report
Int'l Joint Research
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[Book] 臨床神経心理学2018
Author(s)
三村 將、緑川 晶、山口 加代子
Total Pages
232
Publisher
医歯薬出版
ISBN
9784263265611
Related Report
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[Book] 心の科学［第２版］2017
Author(s)
兵藤 宗吉、緑川 晶
Total Pages
256
Publisher
ナカニシヤ出版
ISBN
9784779511431
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