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Effects of extinction of conditioned satiety on the body-weight gain induced by artificial sweetener consumption in rats

Research Project

Project/Area Number 15K04199
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionDoshisha University

Principal Investigator

Aoyama Kenjiro  同志社大学, 心理学部, 教授 (50257789)

Research Collaborator Grimm Jeffrey W.  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords人工甘味料 / 肥満 / 条件づけ / 条件性満腹感 / セッション内変動 / ラット / サッカリン / オペラント行動 / 砂糖渇望 / 渇望の孵化 / 砂糖中毒 / 条件性飽和
Outline of Final Research Achievements

We investigated the effects of artificial sweetener consumption on body-weight gain and operant responding for sugar pellets in rats. Repeated experience of artificial sweetener should extinguish the conditioned satiety response to the sweet taste CS and thus should facilitate chow intake and body-weight gain. In addition, the experience of artificial sweetener should increase operant responding for sugar pellets and alleviate within-session decreases in responding. Results from the experiments supported these predictions. However, we found that maintenance diet was an important mediator for the effects of artificial sweeter consumption on body-weight gain, chow consumption, and operant responding for sugar pellets.

Academic Significance and Societal Importance of the Research Achievements

人工甘味料摂取がラットの体重と飼育用餌の摂取量を増加させる場合がある結果は、先行研究と一致する。加えて、その場合に砂糖を強化子とするレバー押し行動が増加し、レバー押し行動のセッション内減少が緩やかになることは、甘味に対する条件性満腹感の消去が餌摂取量増加と体重増加の原因であるとの仮説を支持する。これらのデータは、人工甘味料摂取が、通常の目的と反対に、体重増加をはじめとする健康悪化につながる可能性を示す一方、条件づけ原理の応用により悪影響を緩和できる可能性をも示唆する。ただし、人工甘味料摂取の効果は飼育用餌の影響を受けたことから、人間の日常生活における影響は慎重に見極める必要がある。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 5 results) Book (1 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Western Washington University(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Western Washington University(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Western Washington University(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Systemic injection of the DAD1 antagonist SCH 23390 reduces saccharin seeking in rats2016

    • Author(s)
      Aoyama, K., Barnes, J., Koerber, J., Glueck, E., Dorsey, K., Eaton, L., & Grimm, J. W.
    • Journal Title

      Appetite

      Volume: 105 Pages: 8-13

    • DOI

      10.1016/j.appet.2016.05.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Repeated consumption of saccharin did not affect operant responding for sugar pellets in rats2019

    • Author(s)
      Aoyama, K
    • Organizer
      Society for the Quantitative Analysis of Behavior 42nd Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] サッカリン摂取によりラットの体重と摂食行動は増加する2018

    • Author(s)
      青山謙二郎
    • Organizer
      日本行動分析学会第36回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Craving for artificial sweetener: Incubation of saccharin craving and involvement of dopamine (DA) D1 receptor2016

    • Author(s)
      Kenjiro Aoyama
    • Organizer
      The 31st International Congress of Psychology
    • Place of Presentation
      PACIFICO Yokohama, JAPAN
    • Year and Date
      2016-07-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of saccharin consumption on body weight and operant-responding reinforced by sucrose in rats2016

    • Author(s)
      Kenjiro Aoyama
    • Organizer
      The Society for the Quantitative Analyses of Behavior
    • Place of Presentation
      Hyatt Regency Chicago, USA
    • Year and Date
      2016-05-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of saccharin consumption on body weight and operant-responding reinforced by sucrose in rats2016

    • Author(s)
      Aoyama, K.
    • Organizer
      Society for the Quantitative Analysis of Behavior 39th Annual Meeting
    • Place of Presentation
      Chicago(アメリカ合衆国)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Craving for artificial sweetener: Incubation of saccharin craving and involvement of dopamine (DA) D1 receptors2016

    • Author(s)
      Aoyama, K.
    • Organizer
      31st International Congress of Psychology
    • Place of Presentation
      Pacifico Yokohama(神奈川県・横浜市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 人工甘味料摂取によりラットの体重は増加する:サッカリン摂取が体重及び砂糖ペレット摂取行動に及ぼす影響2016

    • Author(s)
      青山謙二郎
    • Organizer
      日本行動分析学会第34回年次大会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Related Report
      2016 Research-status Report
  • [Book] 心理学からみた食べる行動-基礎から臨床までを科学する-2017

    • Author(s)
      青山謙二郎・武藤崇(編著)
    • Total Pages
      290
    • Publisher
      北大路書房
    • ISBN
      9784762829741
    • Related Report
      2017 Research-status Report
  • [Remarks] 人工甘味料のワナ

    • URL

      https://psych.doshisha.ac.jp/staff/aoyama/studyc.html

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
  • [Funded Workshop] Doshisha Symposium on Learning and Motivation2016

    • Place of Presentation
      同志社大学
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2022-02-21  

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