Decoding others' reward signals affecting valuation of self rewards - a role of the primate lateral hypothalamus

• Project/Area Number: 15K04200
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental psychology
• Research Institution: National Institute for Physiological Sciences (2017); Kansai Medical University (2015-2016)
• Principal Investigator: NORITAKE Atsushi 生理学研究所, システム脳科学研究領域, 助教 (80407684)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 報酬 / 社会 / 視床下部外側野 / 自己および他者 / 霊長類 / 学習 / 自己と他者

Outline of Final Research Achievements

Primates, including human beings, are thought to be social animals in nature. Cortical neuron mechanisms of social learning and social adaptation have often been discussed, whereas subcortical neuron mechanisms remain unclear. This study investigated whether and how information of reward to others influenced anticipatory behavior for rewards to oneself and the neuronal representation in the primate lateral hypothalamus. Our physiological and pharmacological experiments have revealed that neurons in the lateral hypothalamus encoded signals of self-reward and other-reward values in an integrated manner (subjective value) and that their activity was profoundly involved in the anticipatory licking behavior for rewards. These findings may extend current learning theories based on self-reward information to those based on not only self-reward but also other-reward information and provide valuable insights into our social behavior.

Research Products

• [Presentation] サル大脳皮質・皮質下回路における自己および他者の報酬情報表現 (2018)
  • Author(s): 則武厚
  • Organizer: 第7回新潟脳研-霊長研-生理研合同シンポジウム
• [Presentation] Neural networks for social reward valuation in the macaque brain (2017)
  • Author(s): Noritake A
  • Organizer: The 7th NIPS/CIN Joint Symposium
  • Int'l Joint Research
• [Presentation] Multiple social reward signals in the macaque brain (2017)
  • Author(s): Noritake A
  • Organizer: 第40回日本神経科学大会
• [Presentation] 霊長類ドパミン細胞の活動は他者への報酬見込みによって影響を受ける Activity of primate dopamine neurons is influenced by the prospect of others’ reward (2016)
  • Author(s): Noritake A., Isoda M.
  • Organizer: 第39回日本神経科学大会（パシフィコ横浜）
  • Place of Presentation: Pacifico Yokohama (Yokohama, Japan)
• [Presentation] Social reward signals in primate lateral hypothalamic neurons: comparison with prefrontal and midbrain dopamine neurons (2016)
  • Author(s): Noritake A., Isoda M.
  • Organizer: 第47回北米神経科学大会（サンディエゴコンベンションセンター）
  • Place of Presentation: San Dieago Convention Center (San Diego, USA)
  • Int'l Joint Research
• [Presentation] Social reward valuation in primate midbrain dopamine cells (2015)
  • Author(s): Noritake A., Isoda M.
  • Organizer: 第45回北米神経科学大会
  • Place of Presentation: シカゴ（アメリカ合衆国）
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Remarks] 生理学研究所 システム脳科学研究領域 認知行動発達機構研究部門
  • URL: https://www.nips.ac.jp/dbd/dbd_ja/index.html