Development of Simple Method for Synthesis of Magnetic Nanoparticles Optimized for Hyperthermia in Cancer Treatments and High-Precision Method for Estimation of Induction Heating

• Project/Area Number: 15K04625
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nanomaterials engineering
• Research Institution: Osaka Prefecture University
• Principal Investigator: IWASAKI Tomohiro 大阪府立大学, 工学(系)研究科(研究院), 准教授 (50295721)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: マグネタイト / 磁性ナノ粒子 / 磁性流体 / 誘導加熱 / 結晶子径分布 / 磁気ハイパーサーミア

Outline of Final Research Achievements

The particle size distribution of magnetic nanoparticles as a heating mediator was experimentally determined from the X-ray diffraction pattern. The experimental data of the induction heating in an alternating magnetic field was compared with the theoretical values calculated taking into account the particle size distribution. The results demonstrate that the induction heating can be well estimated using both the physical properties of magnetic fluid and the conditions of alternating magnetic field. Furthermore, the numerical model for estimating the induction heating provides knowledge of the particle size distribution of magnetic nanoparticles suitable for hyperthermia treatments. The important operating factors for controlling the induction heating are also identified.

Research Products

• [Presentation] Effect of Gd Substitution on Magnetic Induction Heating Properties of Mg-Zn Ferrites (2017)
  • Author(s): Fumie Hirosawa, Tomohiro Iwasaki, Satoru Watano
  • Organizer: The 15th International Conference on Advanced Materials (IUMRS-ICAM 2017)
  • Int'l Joint Research
• [Presentation] Mechanochemically Assisted Synthesis of Magnetite/Hydroxyapatite Hybrid Biomaterials for Magnetic Hyperthermia (2016)
  • Author(s): Tomohiro Iwasaki, Ryo Nakatsuka, Fumie Hirosawa, Satoru Watano
  • Organizer: 9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM 9)
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-08-01
  • Int'l Joint Research
• [Presentation] Induction Heating Properties of Gd-substituted Mg-Zn Ferrite Nanoparticles in an AC Magnetic Field (2016)
  • Author(s): Fumie Hirosawa, Tomohiro Iwasaki, Satoru Watano
  • Organizer: 9th Pacific Rim International Conference on Advanced Materials and Processing (PRICM 9)
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-08-01
  • Int'l Joint Research
• [Presentation] Wet Ball Milling Process for Synthesis of Water-based Magnetite Magnetic Fluids (2015)
  • Author(s): Tomohiro Iwasaki, Tsukasa Kagawa, Satoru Watano
  • Organizer: The 3rd International Conference on Powder Metallurgy in Asia (APMA2015)
  • Place of Presentation: 京都大学（京都府京都市）
  • Year and Date: 2015-11-09
  • Int'l Joint Research
• [Presentation] One-step Mechanochemical Synthesis of Water-based Magnetite Magnetic Fluids (2015)
  • Author(s): Tomohiro Iwasaki, Tsukasa Kagawa, Satoru Watano
  • Organizer: The 6th Asian Particle Technology Symposium (APT2015)
  • Place of Presentation: ソウル（韓国）
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Book] Magnetic Spinels - Synthesis, Properties and Applications (2017)
  • Author(s): Barbara Pacakova, Silvia Soreto, Oscar Perales-Perez, Subhash Thota, Chuan-Chuan Gu, Weiwei Xie, Rajender Singh, Tomohiro Iwasaki, Oscar F. Odio, Patrick Mountapmbeme Kouotou, Malik Anjelh Baqiya, Pengjun Ma, Katerina Nechvilova 他
  • Total Pages: 314
  • Publisher: InTech