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Photothermal nano heater for medicine applications

Research Project

Project/Area Number 15K04679
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thin film/Surface and interfacial physical properties
Research InstitutionThe University of Tokushima

Principal Investigator

Yanagiya Shin-ichiro  徳島大学, 大学院社会産業理工学研究部(理工学域), 助教 (40314851)

Co-Investigator(Kenkyū-buntansha) 後藤 信夫  徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (60170461)
Research Collaborator SEKIMOTO Naoya  
TAKAHATA Toshihiko  
MATSUOKA Hiroya  
MATSUMURA Hisatomo  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords金ナノ粒子 / 表皮角層 / 熱プラズモニクス / 光熱ダイナミクス / その場観察法 / 表皮角層細胞 / 原子間力顕微鏡法 / レーザープロセッシング / 光熱治療 / プラズモニクス / マイクロバブル / グラフェン / 光学顕微鏡法 / フォトニクス
Outline of Final Research Achievements

The main purpose of the study is to achieve the photothermal devices for the nano heating of biological tissues. We reported the following findings and demonstrations as nano material science: ① the fabrication of micro glass beads coated with gold nanoparticles (AuNP) and the investigations for their photothermal effects, ② the microscopic Raman study of graphene on 4H-SiC two-dimensionally enhanced by AuNPs, and ③ optical properties of titanium dioxide sputtered film deposited on two-dimensionally assembled AuNP. And the achievements for photothermal bubbles are as follows: ④ micro- and nano-scopic study of fine bubbles generated by photothermal of AuNPs and ⑤ growth and shrinkage of microbubbles in water-alcohol mixture generated by photoexcitation of AuNP. In addition, we also reported the followings as biomechanical science: ⑥ the mechanical properties of stratum corneum in glycerin solution and ⑦ nano mechanical properties of corneocyte by atomic force microscopy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (17 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Microscopic Study of Microbubbles Generated by Photoexcitation of Gold Nanoparticles2017

    • Author(s)
      柳谷伸一郎
    • Journal Title

      Journal of the Japan Society for Precision Engineering

      Volume: 83 Issue: 7 Pages: 631-635

    • DOI

      10.2493/jjspe.83.631

    • NAID

      130006855953

    • ISSN
      0912-0289, 1882-675X
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Microscopic Raman Study of Graphene on 4H-SiC Two-Dimensionally Enhanced by Surface Roughness and Gold Nanoparticles2016

    • Author(s)
      H. Matsumura, S. Yanagiya, M. Nagase, H. Kishikawa and N. Goto
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 55 Issue: 6S1 Pages: 06GL05-06GL05

    • DOI

      10.7567/jjap.55.06gl05

    • NAID

      120006380969

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Microscopic Raman Study of Graphene on 4H-SiC Two-Dimensionally Enhanced by Surface Roughness and Gold Nanoparticles2016

    • Author(s)
      Hisatomo Matsumura, Shin-ichiro Yanagiya, Masao Nagase, Hiroki Kishikawa and Nobuo Goto
    • Journal Title

      Japanese Journal of Applied Physics, Part 1

      Volume: 55

    • NAID

      120006380969

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mechanical Properties of Stratum Corneum in Glycerin Solution by Atomic Force Microscopy2015

    • Author(s)
      Shin-ichiro Yanagiya, Aiko Takahashi and Nobuo Goto
    • Journal Title

      e-Journal of Surface Science and Nanotechnology

      Volume: 13 Issue: 0 Pages: 461-464

    • DOI

      10.1380/ejssnt.2015.461

    • NAID

      130005113019

    • ISSN
      1348-0391
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Mechanical properties of human corneocyte on gel sheet by atomic force microscopy2017

    • Author(s)
      Matsuoka Hiroya, Shin-ichiro Yanagiya and Akihiro Furube
    • Organizer
      25th International Colloquium on Scanning Probe Microscopy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thermoplasmonics of micro glassbead coated with gold nanoparticles2017

    • Author(s)
      Naoya Sekimoto, Shin-ichiro Yanagiya and Akihiro Furube
    • Organizer
      Microoptics Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transient absorption of titanium dioxide sputtered film deposited on two-dimensionally assembled gold nanoparticles2017

    • Author(s)
      Toshihiko Takahata, Shin-ichiro Yanagiya and Akihiro Furube
    • Organizer
      Microoptics Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 熱プラズモニックビーズによる光トラップ可能なマイクロバブルジェネレーターの提案2017

    • Author(s)
      柳谷 伸一郎, 関本 直也
    • Organizer
      マイクロ・ナノバブル学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 金ナノ粒子二次元膜上への酸化チタンスパッタ膜の積層化と過渡吸収法による光学特性評価2017

    • Author(s)
      高畑 敏彦, 柳谷 伸一郎, 古部 昭広
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 表皮角層細胞の薄い弾性体モデル化に対する研究2017

    • Author(s)
      松岡 宏哉, 柳谷 伸一郎, 古部 昭広
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 熱プラズモニックビーズの作製と水中での光ナノ加熱2017

    • Author(s)
      関本 直也, 柳谷 伸一郎, 古部 昭広
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 金ナノ粒子修飾したマイクロガラスビー ズの光ピンセット効果2017

    • Author(s)
      関本 直也, 柳谷 伸一郎, 古部 昭広
    • Organizer
      応用物理・物理系学会 中国四国支部 合同学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 金ナノ粒子二次元膜上への酸化チタンス パッタ膜の積層化と光学特性評価2017

    • Author(s)
      高畑 敏彦, 柳谷 伸一郎, 古部 昭広
    • Organizer
      応用物理・物理系学会 中国四国支部 合同学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] レーザー損傷した表皮角層細胞の原子間力顕微鏡観察2017

    • Author(s)
      松岡 宏哉, 柳谷 伸一郎, 古部 昭広
    • Organizer
      第64回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Presentation] アルコール水溶液中で発生する光熱バブルの寿命に関する研究2016

    • Author(s)
      柳谷 伸一郎, 吉田 篤志, 古部 昭広
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Research-status Report
  • [Presentation] ゲルシート上に置いた表皮角層細胞のフォースカーブ測定2016

    • Author(s)
      松岡 宏哉, 柳谷 伸一郎, 古部 昭広
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Growth and Shrinkage of Microbubbles in Water-Alcohol Mixture generated by Photoexcitation of Gold Nanoparticles2016

    • Author(s)
      Shin-ichiro Yanagiya, Yoshida Atsushi and Akihiro Furube
    • Organizer
      18th International Conference on Crystal Growth and Epitaxy
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2016-08-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surface Enhanced Raman Spectroscopy of Graphene by Gold Nanoparticles with Micro Beads2015

    • Author(s)
      Hisatomo Matsumura, Shin-ichiro Yanagiya, Hiroki Kishikawa and Nobuo Goto
    • Organizer
      28th International Microprocesses and Nanotechnology Conference
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Microscopic Raman spectroscopy of graphene enhanced by gold nanoparticles and micro glass bead2015

    • Author(s)
      Hisatomo Matsumura, Shin-ichiro Yanagiya, Hiroki Kishikawa and Nobuo Goto
    • Organizer
      20th Microoptics conference (MOC '15)
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 金ナノ粒子のレーザー加熱による微細バブル生成のLCM/AFMその場観察2015

    • Author(s)
      柳谷伸一郎
    • Organizer
      第45回結晶成長国内会議
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 金ナノ粒子の自己組織膜による(AuNPs)を用いたグラフェンの増強ラマン増強効果2015

    • Author(s)
      松村 尚知, 柳谷 伸一郎, 岸川 博紀, 後藤 信夫
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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