| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In neutron protein crystallography, the incoherent scattering from hydrogen atoms involved in a protein single-crystal and the surrounding water molecules is significantly large, resulting in backgrounds on neutron diffraction experiment. The diffracted intensities from a protein single-crystal are very weak as the number of reflections increases with larger unit cells. This has difficulty in discriminating between coherent signal and backgrounds especially for the Bragg reflections diffracted from biomacromolecules with large unit-cells. We are planning to build the neutron single-crystal diffractometer in J-PARC/MLF. In this study, I performed the feasibility studies to precisely integrate weak reflections characterized by the single-crystal neutron diffractometry and developed the new data reduction protocol. In addition, I designed a new versatile diffractometer dedicated for biomacromolecules with large unit cells.
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