Elucidation of the mechanism of erythrocyte aggregation: bridging model and depletion model
| Project/Area Number |
15K05240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 赤血球 / フィブリノゲン / 糖鎖 / グリコシダーゼ / 赤血球集合 / 水晶振動子マイクロバランス / 赤血球沈降速度 / トリプシン / ノイラミニダーゼ / ゼータ電位 / シアル酸 / ポリエチレングリコール / コンカナバリンA |
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| Outline of Final Research Achievements |
When erythrocytes are suspended in a plasma or other macromolecular solutions, they form face-to-face aggregates called rouleaux, which are easily broken up by mechanical shearing. It has been pointed out that enhanced erythrocyte aggregation affects in vivo blood flow. There are two models for erythrocyte aggregation: the bridging model and the depletion model. The bridging model assumes the adsorption of macromolecules onto the erythrocyte membranes. On the other hand, the depletion model assumes the osmotic attractive forces due to macromolecular depletion near the erythrocyte surface. In this study, the interaction between erythrocytes and fibrinogen molecules was measured by quartz crystal microbalance. The results suggested that erythrocyte aggregation was caused by the mechanism of macromolecular bridging.
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Report
(4 results)
Research Products
(18 results)
