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Theoretical study on the universal behaviors in cell rheology

Research Project

Project/Area Number 15K05250
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological physics/Chemical physics/Soft matter physics
Research InstitutionTokyo Metropolitan University

Principal Investigator

Komura Shigeyuki  首都大学東京, 理工学研究科, 准教授 (90234715)

Co-Investigator(Kenkyū-buntansha) 岡本 隆一  岡山大学, 異分野基礎科学研究所, 特任講師 (10636385)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマイクロレオロジー / ソフトマター / 細胞 / 異常拡散 / 揺動散逸定理 / マイクロマシン / マイクロスイマー / ブラウン・ラチェット
Outline of Final Research Achievements

With the development of the new experimental technique called microrheology, many knowledges concerning cell rheology have been accumulating all over the world in the last decade. In this research project, with the aim to understand the universal behaviors in cell rheology within soft matter physics and nonequilibrium physics, we have developed fundamental theories for microrheology that is applicable to inhomogeneous and nonequilibrium systems. Furthermore, we have established a new microrheology method that is suitable for investigating mechanical responses in cells coated with biomembranes. In particular, we have established the followings: (i) basic theory for membrane microrhelogy, (ii) active microrheology in multi-component media, and (iii) detection of non-thermal fluctuations by using microrhelogy methods.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (61 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (8 results) Journal Article (21 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 21 results,  Acknowledgement Compliant: 12 results,  Open Access: 1 results) Presentation (29 results) (of which Int'l Joint Research: 20 results,  Invited: 8 results) Remarks (2 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Tel Aviv University(Israel)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Indian Institute of Technology(India)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University Paris Diderot(France)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Tel Aviv University(Israel)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Indian Institute of Technology(India)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University Paris Diderot(France)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Tel Aviv University(Israel)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Universite Paris Diderot(France)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Kosmotropic effect leads to LCST decrease in thermoresponsive polymer solutions2018

    • Author(s)
      Swaminath Bharadwaj, P. B. Sunil Kumar, Shigeyuki Komura, and Abhijit P. Deshpande
    • Journal Title

      The Journal of Chemical Physics

      Volume: 148 Issue: 8

    • DOI

      10.1063/1.5012838

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Thermal and active fluctuations of a compressible bilayer vesicle2018

    • Author(s)
      T V Sachin Krishnan, Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Journal of Physics: Condensed Matter

      Volume: 30 Issue: 17 Pages: 175101-175101

    • DOI

      10.1088/1361-648x/aab6c7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamics of a bilayer membrane with membrane-solvent slip boundary conditions2018

    • Author(s)
      Kento Yasuda, Ryuichi Okamoto, Shigeyuki Komura, and Jean-Baptiste Fournier
    • Journal Title

      Soft Materials

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lateral diffusion induced by active proteins in a biomembrane2017

    • Author(s)
      Yuto Hosaka, Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Physical Review E

      Volume: 95 Issue: 5

    • DOI

      10.1103/physreve.95.052407

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of a bilayer membrane coupled to a two-dimensional cytoskeleton: Scale transfers of membrane deformations2017

    • Author(s)
      Ryuichi Okamoto, Shigeyuki Komura, and Jean-Baptiste Fournier
    • Journal Title

      Physical Review E

      Volume: 96 Issue: 1

    • DOI

      10.1103/physreve.96.012416

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Elastic three-sphere microswimmer in a viscous fluid2017

    • Author(s)
      Kento Yasuda, Yuto Hosaka, Mizuki Kuroda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86 Issue: 9 Pages: 093801-093801

    • DOI

      10.7566/jpsj.86.093801

    • NAID

      210000134497

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermally driven elastic micromachines2017

    • Author(s)
      Yuto Hosaka, Kento Yasuda, Isamu Sou, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86 Issue: 11 Pages: 113801-113801

    • DOI

      10.7566/jpsj.86.113801

    • NAID

      40021376928

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coexistences of lamellar phases in ternary surfactant solutions2017

    • Author(s)
      Isamu Sou, Ryuichi Okamoto, Shigeyuki Komura, and Jean Wolff
    • Journal Title

      Soft Materials

      Volume: 15 Issue: 4 Pages: 272-281

    • DOI

      10.1080/1539445x.2017.1354024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Permeation through a lamellar stack of lipid mixtures2017

    • Author(s)
      Takuma Hoshino, Shigeyuki Komura, and David Andelman
    • Journal Title

      EPL

      Volume: 120 Issue: 1 Pages: 18004-18010

    • DOI

      10.1209/0295-5075/120/18004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Swimmer-microrheology2017

    • Author(s)
      Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 86 Issue: 4 Pages: 043801-043801

    • DOI

      10.7566/jpsj.86.043801

    • NAID

      210000134327

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anomalous diffusion in viscoelastic media with active force dipoles2017

    • Author(s)
      Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Physical Review E

      Volume: 95 Issue: 3

    • DOI

      10.1103/physreve.95.032417

    • NAID

      130006711066

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Localization and diffusion of tracer particles in viscoelastic media with active force dipoles2017

    • Author(s)
      Kento Yasuda, Ryuichi Okamoto, Shigeyuki Komura, and Alexander S. Mikhailov
    • Journal Title

      EPL

      Volume: 117 Issue: 3 Pages: 38001-38001

    • DOI

      10.1209/0295-5075/117/38001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Spherically symmetric solvent is sufficient to explain lower critical solution temperature in polymer solutions2017

    • Author(s)
      Swaminath Bharadwaj, Palakurissi B. Sunil Kumar, Shigeyuki Komura, Abhijit P. Deshpande
    • Journal Title

      Macromolecular Theory and Simulations

      Volume: 26 Issue: 2

    • DOI

      10.1002/mats.201600073

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Relaxation dynamics of a compressible bilayer vesicle containing highly viscous fluid2016

    • Author(s)
      T. V. Sachin Krishnan, Ryuichi Okamoto, and Shigeyuki Komura
    • Journal Title

      Physical Review E

      Volume: 94 Issue: 6 Pages: 062414-062414

    • DOI

      10.1103/physreve.94.062414

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Budding transition of asymmetric two-component lipid domains2016

    • Author(s)
      Jean Wolff, Shigeyuki Komura, and David Andelman
    • Journal Title

      Physical Review E

      Volume: 94 Issue: 3

    • DOI

      10.1103/physreve.94.032406

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phase diagrams and ordering in charged membranes: Binary mixtures of charged and neutral lipids2016

    • Author(s)
      Naofumi Shimokawa, Hiroki Himeno, Tsutomu Hamada, Masahiro Takagi, Shigeyuki Komura, David Andelman
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 120 Issue: 26 Pages: 6358-6367

    • DOI

      10.1021/acs.jpcb.6b03102

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dynamics of a membrane interacting with an active wall2016

    • Author(s)
      Kento Yasuda, Shigeyuki Komura, and Ryuichi Okamoto
    • Journal Title

      Physical Review E

      Volume: 93 Issue: 5

    • DOI

      10.1103/physreve.93.052407

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nano-domain formation in charged membranes: Beyond the Debye-Huckel approximation2016

    • Author(s)
      Ryuichi Okamoto, Naofumi Shimokawa, Shigeyuki Komura
    • Journal Title

      Europhysics Letters

      Volume: 114 Issue: 2 Pages: 280021-6

    • DOI

      10.1209/0295-5075/114/28002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Relaxation dynamics of two-component fluid bilayer membranes2016

    • Author(s)
      Ryuichi Okamoto, Yuichi Kanemori, Shigeyuki Komura, and Jean-Baptiste Fournier
    • Journal Title

      The European Physical Journal E

      Volume: 39 Issue: 5

    • DOI

      10.1140/epje/i2016-16052-3

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Correlated lateral phase separations in stacks of lipid membranes2015

    • Author(s)
      T. Hoshino, S. Komura, and D. Andelman
    • Journal Title

      J. Chem. Phys.

      Volume: 143 Issue: 24

    • DOI

      10.1063/1.4934984

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dynamics of two-component membranes surrounded by viscoelastic media2015

    • Author(s)
      S. Komura, K. Yasuda, and R. Okamoto
    • Journal Title

      J. Phys.: Condens. Matter

      Volume: 27 Issue: 43 Pages: 432001-432001

    • DOI

      10.1088/0953-8984/27/43/432001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] スイマー・マイクロレオロジー2018

    • Author(s)
      好村滋行, 安田健人, 岡本隆一
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二つの三つ玉スイマーの協同運動2018

    • Author(s)
      黒田瑞季, 安田健人, 保阪悠人, 岡本隆一, 好村滋行
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 熱的に駆動される弾性的なマイクロマシン2018

    • Author(s)
      安田健人, 保阪悠人, 曹勇, 好村滋行, 岡本隆一
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 分子マシンのアクティブダイマーモデル2018

    • Author(s)
      保阪悠人, 好村滋行, Alexander S. Mikhailov
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 皮膚ガンのパターン形成における流体力学的効果2018

    • Author(s)
      星野拓馬, 好村滋行, 陳宣毅, 呉國安
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小腸絨毛の形態形成のダイナミクス2018

    • Author(s)
      梅村侑生, 星野拓馬, 好村滋行
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 基板上の生体組織の広がりダイナミクス2018

    • Author(s)
      山下晃史, 星野拓馬, 好村滋行
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 異なる温度を持つ三つ球マイクロマシンの確率流解析2018

    • Author(s)
      曹勇, 保阪悠人, 安田健人, 好村滋行
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Swimmer-microrheology2017

    • Author(s)
      Shigeyuki Komura
    • Organizer
      Association in Solution IV, St. John’s, Canada
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Elastic three-sphere microswimmer in a viscous fluid2017

    • Author(s)
      Mizuki Kuroda, Kento Yasuda, Yuto Hosaka, Ryuichi Okamoto, and Shigeyuki Komura
    • Organizer
      Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anomalous diffusion in viscoelastic media with active force dipoles2017

    • Author(s)
      Shigeyuki Komura, Kento Yasuda, Ryuichi Okamoto, and Alexnder S. Mikhailov
    • Organizer
      Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pattern formation of skin cancer: Effects of hydrodynamic interactions2017

    • Author(s)
      Takuma Hoshino, Shigeyuki Komura, Hsuan-Yi Chen, and Kuo-An Wu
    • Organizer
      Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stochastic properties of an active force dipole2017

    • Author(s)
      Yuto Hosaka, Shigeyuki Komura, and Alexander S. Mikhailov
    • Organizer
      Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Swimmer-microrheology2017

    • Author(s)
      Kento Yasuda, Ryuichi Okamoto, and Shigeyuki Komura
    • Organizer
      Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Morphogenesis of small intestinal villus2017

    • Author(s)
      Yuki Umemura, Takuma Hoshino, and Shigeyuki Komura
    • Organizer
      Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coexistences of lamellar phases in ternary surfactant solutions2017

    • Author(s)
      Isamu Sou, Ryuichi Okamoto, Shigeyuki Komura, and Jean Wolff
    • Organizer
      Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamics of the cell membrane coupled to cytoskeleton2017

    • Author(s)
      Chia-Chun Liang, Kento Yasuda, Shigeyuki Komura, and Hsuan-Yi Chen
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2017, Sendai, Japan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anomalous diffusion in active cells2016

    • Author(s)
      Shigeyuki Komura
    • Organizer
      International Workshop on Hydrodynamic Flows in/of Cells
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Anomalous diffusion in active cells2016

    • Author(s)
      Shigeyuki Komura
    • Organizer
      Interdisciplinary Applications of Nonlinear Science
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamics of multi-component membranes2016

    • Author(s)
      Shigeyuki Komura
    • Organizer
      4th International Kyushu Colloid Colloquium
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2016-09-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Anomalous diffusion in active cells2016

    • Author(s)
      Shigeyuki Komura
    • Organizer
      BioSoft Frontiers: Physics of Soft and Biological Matter
    • Place of Presentation
      Rehovot & Tel Aviv, Israel
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamics of a membrane interacting with an active wall2016

    • Author(s)
      Kento Yasuda, Shigeyuki Komura, and Ryuichi Okamoto
    • Organizer
      4th International Soft Matter Conference
    • Place of Presentation
      Grenoble, France
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nano-domain formation in a charged membrane2016

    • Author(s)
      Ryuichi Okamoto, Naofumi Shimokawa, and Shigeyuki Komura
    • Organizer
      4th International Soft Matter Conference
    • Place of Presentation
      Grenoble, France
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Correlated lateral phase separations in stacks of lipid membranes2016

    • Author(s)
      Takuma Hoshino, Shigeyuki Komura, and David Andelman
    • Organizer
      4th International Soft Matter Conference
    • Place of Presentation
      Grenoble, France
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relaxation dynamics of two-component fluid bilayer membranes2016

    • Author(s)
      Shigeyuki Komura, Ryuichi Okamoto, and Jean-Baptiste Fournier
    • Organizer
      4th International Soft Matter Conference
    • Place of Presentation
      Grenoble, France
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structural rheology of the smectic phase2016

    • Author(s)
      Shigeyuki Komura
    • Organizer
      6th International Mini-workshop
    • Place of Presentation
      Chiba, Japan
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂質膜におけるメソ構造2015

    • Author(s)
      岡本隆一, 好村滋行
    • Organizer
      日本物理学会・2015年秋季
    • Place of Presentation
      関西大学, 吹田市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Relaxation Dynamics of Binary Lipid Bilayers2015

    • Author(s)
      S. Komura
    • Organizer
      International Symposium on Fluctuation and Structure out of Equilibrium 2015
    • Place of Presentation
      Kyoto University, Japan
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamics of multi-component membranes2015

    • Author(s)
      S. Komura
    • Organizer
      Controlled Structural Formation of Soft Matter
    • Place of Presentation
      Kavli Institute for Theoretical Physics China, China
    • Year and Date
      2015-08-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 好村滋行のバイオ・ソフトマター研究

    • URL

      http://www.comp.tmu.ac.jp/shigekomura/

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 好村滋行のソフトマター研究

    • URL

      http://www.comp.tmu.ac.jp/shigekomura/

    • Related Report
      2015 Research-status Report
  • [Funded Workshop] International Workshop on Hydrodynamic Flows in/of Cells2016

    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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