Non-average structure of particles in liquid studied by fast single-particle analysis using femtosecond X-ray pulses
| Project/Area Number |
15K05407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Japan Synchrotron Radiation Research Institute |
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Principal Investigator |
Tono Kensuke 公益財団法人高輝度光科学研究センター, XFEL利用研究推進室, 主幹研究員 (00353508)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | X線自由電子レーザー / X線構造解析 / X線回折 / 動的構造解析 |
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| Outline of Final Research Achievements |
Function analysis of biological materials has been performed at the SPring-8 Angstrom Compact Free Electron Laser (SACLA) by using a newly developed experimental system for obtaining dynamical structure of micrometer-scale particles. A pulsed droplet injector was developed as an efficient sample delivery tool in the experimental system, which was successfully applied to the structure analysis of small protein crystals. By combining with an optical laser, this system was able to capture structural dynamics of photo-responsive protein. These studies demonstrate that the new experimental system is highly useful for function analysis of materials.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Microcrystals delivery by pulsed liquid droplet for serial femtosecond crystallography2016
Author(s)
Fumitaka Mafune, Ken Miyajima, Kensuke Tono, Yoshihiro Takeda, Jun-ya Kohno, Naoya Miyauchi, Jun Kobayashi, Yasumasa Joti, Eriko Nango, So Iwata, Makina Yabashi
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Journal Title
Acta Crystallographica Section D: Biological Crystallography
Volume: 72
Issue: 4
Pages: 520-523
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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