| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The signs at around 295 nm of the CD spectra of the DNA and RNA double-helical structures are much different between the right- and left-handed structures as well as between DNA and RNA. The SAC-CI CD spectra reproduced the features at around 295 nm of the experimental CD spectra of each DNA and RNA, and elucidated that the strong stacking interaction between the two base pairs is the origin of the negative peaks at 295 nm of the CD spectra for both DNA and RNA.
The microbial rhodopsin contains a proton pumping bacteriorhodopsin (BR), a chloride pumping halorhodopsin (HR) and a sodium-ion pumping rhodopsin (KR2). The SAC-CI studies elucidated the geometries of amino acids and water around the retinal in each intermediate, and proposed the ion-pumping mechanisms of BR, HR and KR2.
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