Catalytic Syntheses of Organofluorine Compounds Based on Fluorine-Substituted Complexes
| Project/Area Number |
15K05414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
FUCHIBE Kohei 筑波大学, 数理物質系, 准教授 (10348493)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 触媒 / フッ素 / カルベン錯体 / 医薬 / 農薬 / ニッケル / 銅 / ビニリデン / カルベン / フルオロアルケン / シリルエノールエーテル / 付加環化 / シクロプロパン |
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| Outline of Final Research Achievements |
Organofluorine compounds have increased their importance as pharmaceuticals and agrochemicals especially in recent years. We have focused our attention on difluorocarbene complexes that realize highly efficient syntheses of organofluorine compounds with metal catalysts. It was disclosed that nickel(II) and copper(I) complexes generate the corresponding difluorocarbene complexes and that selective syntheses of isomeric α,α- and β,β-difluorocyclopentanone derivatives, starting from common silyl dienol ethers, were facilitated. The structures which we successfully constructed in this project were commonly found in those of biologically active compounds, leading to development and efficient manufacturing of pharmaceuticals and agrochemicals in future.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Facile Synthesis of Polycyclic Aromatic Hydrocarbons: Bronsted Acid-Catalyzed Dehydrative Cycloaromatization of Carbonyl Compounds in 1,1,1,3,3,3- Hexafluoropropan-2-ol2017
Author(s)
Fujita, T.; Takahashi, I.; Hayashi, M.; Wang, J.; Fuchibe, K.; Ichikawa, J.
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Journal Title
European Journal of Organic Chemistry
Volume: 2
Issue: 2
Pages: 262-265
DOI
Related Report
Peer Reviewed
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