Exploration of Fluorescent Ligands based on Quinoline and Isoquinoline
| Project/Area Number |
15K05454
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nara Women's University |
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Principal Investigator |
Mikata Yuji 奈良女子大学, 自然科学系, 教授 (10252826)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | キノリン / イソキノリン / 蛍光センサー / 亜鉛 / カドミウム / リン酸 / ピロリン酸 / グルコース / モノリン酸 / 水銀 / 鉄 |
|---|
| Outline of Final Research Achievements |
In this study, we have investigated specific fluorescent sensors based on the property of quinoline, and developed several compounds that can strictly discriminate metal ions and anions in environment and living systems. By changing the linker length, nature and number of coordination atoms in the linker and substituents of the quinoline ring, as well as the replacement of quinoline with isoquinoline, we could improve the selectivity toward specific metal ions and anions. We also clarified the mechanism of specificity by X-ray crystallography and theoretical calculations.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Carbohydrate-Appended TQNPEN (N,N,N’,N’-Tetrakis(2-quinolylmethyl)-3-aza-1,5-pentanediamine) Derivatives for Fluorescent Detection of Intracellular Cd2+2018
Author(s)
Y. Mikata, K. Nozaki, M. Kaneda, K. Yasuda, M. Aoyama, S. Tamotsu, and A. Matsumoto
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Journal Title
Eur. J. Inorg. Chem.
Volume: -
Issue: 24
Pages: 2755-2761
DOI
Related Report
Peer Reviewed
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[Journal Article] TQOPEN (N,N,N’,N’-tetrakis(2-quinolylmethyl)-3-oxa-1,5-pentanediamine) family as heptadentate fluorescent Cd2+ sensors2017
Author(s)
Y. Mikata, A. Kizu, K. Nozaki, H. Konno, H. Ono, S. Mizutani, S. Sato
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Journal Title
Inorganic Chemistry
Volume: 56
Issue: 13
Pages: 7404-7415
DOI
Related Report
Peer Reviewed
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[Journal Article] OFF-ON-OFF fluorescent response of N,N,N′,N′-tetrakis(1-isoquinolylmethyl)-2-hydroxy-1,3-propanediamine (1-isoHTQHPN) toward Zn2+2016
Author(s)
Yuji Mikata, Risa Ohnishi, Anna Ugai, Hideo Konno, Yasushi Nakata, Ikuko Hamagamie, Shin-ichiro Sato
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Journal Title
Dalton Transactions
Volume: 45
Issue: 17
Pages: 7250-7257
DOI
Related Report
Peer Reviewed
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