| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we have investigated specific fluorescent sensors based on the property of quinoline, and developed several compounds that can strictly discriminate metal ions and anions in environment and living systems. By changing the linker length, nature and number of coordination atoms in the linker and substituents of the quinoline ring, as well as the replacement of quinoline with isoquinoline, we could improve the selectivity toward specific metal ions and anions. We also clarified the mechanism of specificity by X-ray crystallography and theoretical calculations.
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