| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Recently, the photocontrol of bioactivities using photochromic molecules have been actively studied. For such applications, the irradiation of ultraviolet (UV) light is not desired due to the photodamege and the low permeability of light. Therefore, photoactive molecules that reversibly switch upon visible or near-infrared (NIR) light irradiation are one of the most attractive targets for this research area. In this project, we tried to design and synthesize the fluorescent photochromic diarylethene (DAE) derivatives that photoswitch with NIR light.
One possible approach to prepare such photoswitches is to extend p-conjugation length of molecules and shift the absorption bands to longer wavelengths. In this study, we tried to prepare NIR-light reactive DAE derivatives by introducing fluorescent aromatic dyes at the reactive carbon atoms of the DAE unit. In addition, we also successfully demonstrated the UV-free reversibly photoisomerizations based on the photosensitized reactions.
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