| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Before starting this project, we had found that a certain peptide behaves as a catalyst for a specific addition reaction with high activity and high enantioselectivity. We had uncovered that such a catalytic performance of peptide came from cooperative action of proline and histidine in the peptide chain. We tentatively named this phenomenon as "distal group participation".
This time we tried to clarify how general this "distal group participation" concept is. We tried several reactions with several peptides, and found that this concept could also be applicable toward hydrolysis reaction. In addition, we could find completely new peptide catalyst having proline and histidine. These findings show that there remains further extendability with the "distal group participation".
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