| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Chiral aluminum catalyst system has been developed for the enantioselective vinylation of aldehydes. Disubstituted (E)-vinylaluminum reagents, generated regio- and stereoselectively by the carboalumination of terminal alkynes with trimethylaluminum, were used straightforwardly without transmetalation to vinyltitanium reagents in subsequent enantioselective addition to aldehydes with a 3,5-diphenylphenyl-H8-BINOL-derived chiral aluminum catalyst at low catalyst loading (5 mol%). The reaction afforded the corresponding enantiomerically enriched secondary allylic alcohols with a reversal of selectivity observed in closely relevant reactions catalyzed by a chiral titanium complex derived from the same ligand.
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