Development of Chiral Magnesium and Aluminum Catalysts for Practically Fast Enantioselective Carbonyl Addition Reaction
| Project/Area Number |
15K05500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
Harada Toshiro 京都工芸繊維大学, 分子化学系, 教授 (30135628)
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| Co-Investigator(Kenkyū-buntansha) |
楠川 隆博 京都工芸繊維大学, 分子化学系, 准教授 (70300720)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 不斉触媒 / 不斉合成 / 不斉付加反応 / 合成化学 |
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| Outline of Final Research Achievements |
Chiral aluminum catalyst system has been developed for the enantioselective vinylation of aldehydes. Disubstituted (E)-vinylaluminum reagents, generated regio- and stereoselectively by the carboalumination of terminal alkynes with trimethylaluminum, were used straightforwardly without transmetalation to vinyltitanium reagents in subsequent enantioselective addition to aldehydes with a 3,5-diphenylphenyl-H8-BINOL-derived chiral aluminum catalyst at low catalyst loading (5 mol%). The reaction afforded the corresponding enantiomerically enriched secondary allylic alcohols with a reversal of selectivity observed in closely relevant reactions catalyzed by a chiral titanium complex derived from the same ligand.
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Report
(4 results)
Research Products
(12 results)
