| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Palladium enolates are known not to exhibit any reactivity toward a nucleophile but to react with an electrophile. Nucleophilic interception of the palladium enolate is therefore promising to be a powerful synthetic method of functionalized carbonyl compounds. Through the present study, new catalytic reactions based on palladium enolate umpolung have been successfully developed, which provide an efficient route to valuable bicyclic carbonyl compounds from readily available substrates. These processes involve ring-closing carbon-carbon bond formation and subsequent nucleophilic attack at the resulting palladium enolate intermediate.
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