| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In the field of synthetic organic chemistry, a revolutionary new strategy is needed to achieve “the ideal synthesis”. From this perspective, we focused on sequential metathesis and developed a novel ring-rearrangement metathesis, which allows the one-pot transformation of a strained cyclobutenecarboxylate into a γ-butenolide. In this study, further applications of the ring-rearrangement metathesis were examined and a biomimetic reaction was used to construct more complex structures of natural products. As a result, we achieved the total synthesis and structural revision of clavilactone D. In addition, we succeeded in the synthesis of a biogenetic precursor of aquatolide.
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