| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Development of a simple, rationale, and stereo-defined synthesis of differentially all-carbon tetrasubstituted olefins were performed: vicinal (Z)-dihaloalkenyl silanes were successfully synthesized via addition of in situ generated XX’ to silylethynylarenes, and the vinyl dihalides were employed as synthetic scaffolds for preparation of tetrasubstituted alkenes. When the scaffolds were attempted in the halogen-selective substitution reactions, they suffered from the beta-halogen elimination to put them back to original alkynes; finally, the scaffolds successfully undertook the chemo-selective carbon-carbon bond-forming reactions. This new finding will lead us to synthesis of tetrasubstituted olefins although we don’t yet solve the problematic halogen-elimination side-reactions and simple routes to the olefins.
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