| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
To realize expeditious preparation of PET probes, we proposed a novel synthetic strategy for them by using a bioactive compound in interest as a starting material. In this project, we named the novel strategy “molecular renovation strategy” and developed borylation reactions and a 11C-labeling reaction that are required to realize this idea. Utilizing boron compounds prepared by the newly developed methods as common intermediates, we achieved synthesis of various molecular probes such as a PET probe within two steps, demonstrating practicality of the synthetic strategy.
|
