| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Cinchona alkaloid-peptide hybrid catalysts were established. Chiral squaramidess containing aminated cinchona alkaloid and peptide were prepared. These hybrid catalysts showed high level of stereoselectivities in asymmetric Michael reactions. Cinchona alkaloids contain vinyl group in their molecules. When iodophenyl group was introduced onto the hybrid catalyst, Heck coupling reaction occurred between the hybrid catalyst molecules to form chiral polymers. This is the first synthesis of chiral cinchona squaramide polymer. The polymeric chiral squaramides were used as catalysts in various asymmetric synthesis and showed excellent catalytic performances. In some cases, the polymeric catalysts showed higher stereoselectivity compared to the corresponding low-molecular hybrid catalysts. Since the polymeric catalysts we have developed are insoluble in commonly used organic solvents, the polymeric catalysts were easily recovered and reused many times.
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