| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We developed a supramolecular complex sensor that specifically recognizes phosphate compound derivatives such as ATP (adenosine triphosphate). In this research, selective multipoint recognition for ATP has been achieved by using nano-sized hydrophobic space of cyclodextrin (CyD) and including multiple water insoluble dipicolylamine metal complexes. We have developed two systems based on CyD and metal complex probes with dipicolylamine groups. In a system in which the molecular recognition site was modified to CyD, a selective response to ATP was found. On the other hand, in a system in which a compound having a molecular recognition site is included in modified CyD, a specific interaction with ADP (adenosine diphosphate) by multipoint interaction was found.
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