Development of partially fluorinated phospholipid bilayer membrane
| Project/Area Number |
15K05558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | リン脂質 / フッ素化 / 膜タンパク質 / パーフルオロアルキル基 / 脂質二分子膜 / タンパク質ー脂質相互作用 / 相分離 / 平面脂質膜 / 膜タンパク質－脂質相互作用 / 膜タンパク質ー脂質相互作用 |
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| Outline of Final Research Achievements |
Novel partially fluorinated phospholipids have been developed for structural and functional analysis of membrane proteins in vitro. The partially fluorinated phospholipids showed membrane properties and structure significantly different from the corresponding unfluorinated ones. And it has been demonstrated that a model membrane protein in the partially fluorinated phospholipid bilayer adopts nativelike structure and function.
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Report
(4 results)
Research Products
(31 results)
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[Presentation] Development of Partially Fluorinated Phospholipids: Physicochemical Characterization of Lipid Bilayer and Reconstituted Membrane Protein Bacteriorhodopsin2015
Author(s)
Sonoyama, M.; Yoshino, M.; Morita, K.; Kanayama, K.; Murai, Y.; Hashimoto, M.; Horikoshi, M.; Takahashi, H.; Amii, H.; Takagi, T.; Kanamori, T.; Kikukawa, T.
Organizer
The 5th International Conference on Element Innovation
Place of Presentation
Kiryu City Performing Arts Center
Year and Date
2015-11-30
Related Report
Int'l Joint Research
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