| Project/Area Number |
15K05571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
Miyazaki Tatsuo 新潟薬科大学, 応用生命科学部, 准教授 (70410222)
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| Co-Investigator(Kenkyū-buntansha) |
飛澤 悠葵 弘前大学, 医学研究科, 助教 (70623768)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | カルバ糖鎖 / コア２糖鎖 / モノクローナル抗体 / 癌悪性度診断マーカー |
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| Outline of Final Research Achievements |
For the establishment of a novel cancer malignancy diagnostic method that utilized core 2 oligosaccharide as a tumour marker, two kinds of carba-disaccharides 2 and 3 corresponding to the partial structure of core 2 oligosaccharide (branched trisaccharides) were targeted and the synthesis of the carbasugar acceptors and the sugar donors was examined.
As a result, as carba-sugar block, the synthesis of two kinds of carba- β-D-galactose acceptor 5 and 14 having a hydroxy group at anomeric position and carba-N-acetyl-β-D-glucose 35 were achieved. On the other hand, as sugar block, the synthesis of GalNAc donor 46 having a triflate group at 6-position was achieved in 11 steps. About the synthesis of GulNAc donor having a triflate group at 3-position, the inversion reaction of GalNAc derivative 48 is examining.
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