Study on Biointerfacial Structure Changes Induced by pH Variation

• Project/Area Number: 15K05636
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: Osaka Electro-Communication University
• Principal Investigator: Morita Shigeaki 大阪電気通信大学, 工学部, 教授 (20388739)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 赤外分光 / in situ ATR-IR 法 / 二次元相関法 / バイオマテリアル / 双性イオン性高分子 / 水和構造 / pH / 赤外スペクトル / PCMW2D法

Outline of Final Research Achievements

In order to understand the interfacial structure changes between biomaterials and contacting solutions induced by pH variation, pH-dependent infrared spectra of polymer film in contact with aqueous solution were measured. A series of the obtained spectra was analyzed by means of perturbation-correlation moving-window two-dimensional (PCMW2D) correlation method. Both structure changes in the hydrated polymer chains and hydrating water molecules induced by the pH variation were revealed in the present study.

Research Products

• [Int'l Joint Research] Peking University(中国)
• [Int'l Joint Research] University of Delaware(米国)
• [Journal Article] Novel Method of Constructing Two-Dimensional Correlation Spectroscopy without Subtracting a Reference Spectrum (2018)
  • Author(s): He Anqi、Zeng Yiwei、Kang Xiaoyan、Morita Shigeaki、Xu Yizhuang、Noda Isao、Ozaki Yukihiro、Wu Jinguang
  • Journal Title: The Journal of Physical Chemistry A Volume: 122 Issue: 3 Pages: 788-797
  • DOI: 10.1021/acs.jpca.7b10710
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Moving-window two-dimensional correlation spectroscopy and perturbation-correlation moving-window two-dimensional correlation spectroscopy (2017)
  • Author(s): Morita Shigeaki、Ozaki Yukihiro
  • Journal Title: Chemometrics and Intelligent Laboratory Systems Volume: 168 Pages: 114-120
  • DOI: 10.1016/j.chemolab.2017.07.009
  • Peer Reviewed
• [Presentation] 双性イオン性高分子の pH 依存 ATR-IR スペクトルの解析 (2017)
  • Author(s): 寺西純, 森田成昭
  • Organizer: 第22回高分子分析討論会
• [Presentation] Water Structure in Poly(ω-methoxyalkyl acrylate)s Investigated by ATR-IR Spectroscopy (2017)
  • Author(s): Shigeaki Morita
  • Organizer: 9th International Conference on Advanced Vibrational Spectroscopy
  • Int'l Joint Research
• [Presentation] ATR-IR法とフローセルを組み合わせた分子吸着のその場分析 (2017)
  • Author(s): 森田成昭
  • Organizer: 第77回分析化学討論会
  • Invited
• [Presentation] 赤外分光法とケモメトリックスを組み合わせた含水高分子の分析 (2017)
  • Author(s): 森田成昭
  • Organizer: 高分子分析研究懇談会第389回例会
  • Invited
• [Presentation] in situ ATR-IR 法を用いた抗血栓性高分子材料の水和構造分析 (2017)
  • Author(s): 森田成昭
  • Organizer: 第1回アクアフォトミクス研究会
  • Invited
• [Presentation] Hydration structure of intermediate water in medical polymers (2016)
  • Author(s): Shigeaki Morita
  • Organizer: Japan-Taiwan Medical Spectroscopy International Symposium (JTMSIS)
  • Place of Presentation: 淡路夢舞台国際会議場 （兵庫県・淡路市）
  • Year and Date: 2016-12-04
  • Int'l Joint Research / Invited
• [Presentation] Hydration Structure of Intermediate Water in Medical Polymers (2016)
  • Author(s): Shigeaki Morita
  • Organizer: Aquaphotomics: Understanding Water in Biology 2nd International Symposium
  • Place of Presentation: 神戸大学 六甲台第2キャンパス
  • Year and Date: 2016-11-26
  • Int'l Joint Research / Invited
• [Presentation] 高速赤外分光法によるバイオ界面水の解析 (2016)
  • Author(s): 森田成昭
  • Organizer: 日本バイオマテリアル学会シンポジウム2016
  • Place of Presentation: 福岡国際会議場 （福岡県・福岡市）
  • Year and Date: 2016-11-21
  • Invited
• [Presentation] Perturbation-correlation moving-window two-dimensional (PCMW2D) correlation spectroscopy and its applications (2016)
  • Author(s): Shigeaki Morita
  • Organizer: Asia Symposium on 2DCOS
  • Place of Presentation: 福州大学 （福州市・福建省・中国）
  • Year and Date: 2016-10-28
  • Int'l Joint Research / Invited
• [Presentation] 水和した双性イオン性高分子の赤外スペクトルの考察 (2016)
  • Author(s): 森田成昭
  • Organizer: 平成28年度日本分光学会年次講演会
  • Place of Presentation: 大阪大学 豊中キャンパス
  • Year and Date: 2016-05-24
• [Presentation] In Situ ATR-IR Spectroscopic Observations of Biointerfaces using a Flow Cell (2015)
  • Author(s): Shigeaki Morita
  • Organizer: Pacifichem 2015
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2015-12-15
  • Int'l Joint Research / Invited
• [Presentation] Water Structures in Medical Polymers Explored by In Situ ATR-IR Spectroscopy (2015)
  • Author(s): Shigeaki Morita
  • Organizer: 第25回日本MRS年次大会
  • Place of Presentation: 波止場会館（神奈川県横浜市）
  • Year and Date: 2015-12-08
  • Invited
• [Presentation] カルボキシベタイン系高分子の温度依存赤外スペクトルの解析 (2015)
  • Author(s): 寺西純, 森田成昭
  • Organizer: 第20回高分子分析討論会
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2015-10-27
• [Presentation] in situ ATR-IR 法を用いた双性イオン性バイオマテリアルの水和構造分析 (2015)
  • Author(s): 森田成昭
  • Organizer: 日本分析化学会第64年会
  • Place of Presentation: 九州大学（福岡県福岡市）
  • Year and Date: 2015-09-09
  • Invited
• [Presentation] Concepts and Applications of Perturbation-Correlation Moving-Window Two-Dimensional (PCMW2D) Correlation Spectroscopy (2015)
  • Author(s): Shigeaki Morita
  • Organizer: XV Chemometrics in Analytical Chemistry
  • Place of Presentation: Changsha, China
  • Year and Date: 2015-06-22
  • Int'l Joint Research / Invited
• [Remarks] Shigeaki Morita, Molecular Spectroscopy Laboratory
  • URL: https://sites.google.com/site/shigemorita/