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Development of artificial bone to achieve high bone conductivity

Research Project

Project/Area Number 15K05732
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Production engineering/Processing studies
Research InstitutionKanazawa Institute of Technology

Principal Investigator

shintani kazuhiro  金沢工業大学, 工学部, 教授 (80139758)

Co-Investigator(Renkei-kenkyūsha) Kato Hideharu  金沢工業大学, 工学部, 教授 (90278101)
Kaneuji Ayumi  金沢医科大学, 医学部, 教授 (00303305)
Kawahara Norio  金沢医科大学, 医学部, 教授 (70214674)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords骨伝導 / 切頂八面体 / 3Dハニカム / 層板骨形成 / DLC被膜 / 切頂8面体 / 骨欠損 / 人工足場材 / 股関節 / 脊椎体 / 3Dハニカム / DLC被膜 / 脊椎 / 3Dハニカム / 金属光造形
Outline of Final Research Achievements

For hip osteoarthritis, artificial bone is implanted to improve gait disturbance. This requires strong initial fixation of the implanted artificial bone. Also, in order to maintain the fracture in a normal position and aim for early recovery, it is necessary to induce new bone quickly. Create a 3D honeycomb shape similar to human cancellous bone,It was confirmed by in-vivo test using a dog body that wetting with body fluid was improved by applying a DLC coating on it and showed high bone conducting ability. 3D honeycomb artificial scaffolding material was revealed to be remodeled to a laminar bone with excellent strength characteristics in 12 weeks of implantation. We also performed gene analysis using the microarray method. As a result, it was confirmed that many intrigulin was expressed due to adhesion between bone and artifact.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] DLC被膜を施した3Dハニカム人工足場材が骨伝導能に及ぼす影響2016

    • Author(s)
      新谷一博,小林卓也,他
    • Journal Title

      臨床バイオメカニクス

      Volume: 37 Pages: 35-41

    • NAID

      40020963697

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] DLC被膜を施した3Dハニカム人工足場材が骨伝導能に及ぼす影響2016

    • Author(s)
      新谷一博,小林卓也,中井 遥,川原範夫 他
    • Journal Title

      臨床バイオメカニクス

      Volume: 37

    • NAID

      40020963697

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] a-C:H被膜を施した3Dハニカム足場材料の骨伝導能に関する研究2017

    • Author(s)
      瀨川 歩,新谷一博,田中隆斗,北村鈴香,川原範夫
    • Organizer
      日本臨床バイオメカニクス学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 医療従事者教育用手術モデルの開発2017

    • Author(s)
      駒見宏輔,山田のどか,新谷一博,兼氏歩,桝井伸栄
    • Organizer
      精密工学会北陸信越支部
    • Related Report
      2017 Annual Research Report
  • [Presentation] フッ素含有Diamond like carbon コーティングを用いた整形外科インプラントに使用可能な新規抗菌コーティングの開発2017

    • Author(s)
      米澤克隆,川口真史,兼氏歩,川原範夫,河村佳江,飯沼由嗣,新谷一博,小田忍,瀧真
    • Organizer
      日本脊椎インストゥルメンテーション学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フッ素添加DLCコーティングは骨癒合過程を短縮する2017

    • Author(s)
      佐々本丈嗣,川口真史,米澤克隆,兼氏歩,川原範夫,新谷一博,小田忍
    • Organizer
      日本脊椎インストゥルメンテーション学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 人工足場材料を用いた早期骨固定に関する研究2016

    • Author(s)
      小林卓也,新谷一博 他
    • Organizer
      日本臨床バイオメカニクス学会
    • Place of Presentation
      北海道立道民活動センター
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 腫瘍脊椎骨全摘術におけるセラミックス材料の適用に関する研究2016

    • Author(s)
      川上秀彬,新谷一博 他
    • Organizer
      日本臨床バイオメカニクス学会
    • Place of Presentation
      北海道立道民活動センター
    • Year and Date
      2016-10-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 人工骨表面に施したDLC被膜が骨伝導能に及ぼす影響2015

    • Author(s)
      中井遥,新谷一博,小林卓也,川原範夫 他
    • Organizer
      精密工学会
    • Place of Presentation
      金沢工業大学
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] DLC被膜を施した3Dハニカム構造足場材による骨伝導能の効果2015

    • Author(s)
      小林卓也,新谷一博,中井遥,川原範夫 他
    • Organizer
      臨床バイオメカニクス学会
    • Place of Presentation
      ソラシティカンファレンスセンター
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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