Development of artificial bone to achieve high bone conductivity
| Project/Area Number |
15K05732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Production engineering/Processing studies
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| Research Institution | Kanazawa Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Kato Hideharu 金沢工業大学, 工学部, 教授 (90278101)
Kaneuji Ayumi 金沢医科大学, 医学部, 教授 (00303305)
Kawahara Norio 金沢医科大学, 医学部, 教授 (70214674)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 骨伝導 / 切頂八面体 / 3Dハニカム / 層板骨形成 / DLC被膜 / 切頂８面体 / 骨欠損 / 人工足場材 / 股関節 / 脊椎体 / ３Ｄハニカム / ＤＬＣ被膜 / 脊椎 / 3Ｄハニカム / 金属光造形 |
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| Outline of Final Research Achievements |
For hip osteoarthritis, artificial bone is implanted to improve gait disturbance. This requires strong initial fixation of the implanted artificial bone. Also, in order to maintain the fracture in a normal position and aim for early recovery, it is necessary to induce new bone quickly. Create a 3D honeycomb shape similar to human cancellous bone,It was confirmed by in-vivo test using a dog body that wetting with body fluid was improved by applying a DLC coating on it and showed high bone conducting ability. 3D honeycomb artificial scaffolding material was revealed to be remodeled to a laminar bone with excellent strength characteristics in 12 weeks of implantation. We also performed gene analysis using the microarray method. As a result, it was confirmed that many intrigulin was expressed due to adhesion between bone and artifact.
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Report
(4 results)
Research Products
(10 results)
