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Evaluation of joint prosthesis rubbing surface with low friction property by clarifying adsorption mechanisms of protein molecules

Research Project

Project/Area Number 15K05765
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Design engineering/Machine functional elements/Tribology
Research InstitutionTeikyo University (2017)
Kyushu University (2015-2016)

Principal Investigator

Nakashima Kazuhiro  帝京大学, 福岡医療技術学部, 准教授 (70315109)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords人工関節 / 境界潤滑 / 蛋白質 / 低摩擦 / 吸着膜 / 蛋白質吸着 / ゲル膜 / 生体関節液 / アルブミン / グロブリン / 蛋白質吸着膜
Outline of Final Research Achievements

It was pointed out that albumin and g-globulin included in natural synovial fluid can form cooperative film on joint prosthesis material and as a result the adsorbed film make friction low. In this study, friction and adsorption properties of albumin and g-globulin were investigated to clarify the mechanisms of maintaining low friction.
Albumin showed low friction property and g-globulin showed high adsorption amount. The different property of two kind of protein indicates albumin molecule exhibits low friction of joint prosthesis and g-globulin protects joint prosthesis material from wear. These results suggest that adsorbed protein film shows low friction due to different properties of albumin and g-globulin forming cooperative adsorbed film.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] 人工関節材料に吸着した蛋白質膜のせん断強さ評価2016

    • Author(s)
      中嶋和弘,澤江義則,村上輝夫
    • Journal Title

      臨床バイオメカニクス

      Volume: 37 Pages: 231-235

    • NAID

      40020964253

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 人工関節材料に吸着した蛋白質膜のせん断強さ評価2016

    • Author(s)
      中嶋和弘 澤江義則 村上輝夫
    • Journal Title

      日本臨床バイオメカニクス学会誌

      Volume: 37 Pages: 00-00

    • NAID

      40020964253

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 2種の蛋白質を含む潤滑液中における CoCrMo-UHMWPEの摩擦特性2017

    • Author(s)
      中嶋 和弘, 澤江 義則, Susumu Kudo, 村上 輝夫
    • Organizer
      第37回バイオトライボロジシンポジウム
    • Place of Presentation
      東京都
    • Year and Date
      2017-03-11
    • Related Report
      2016 Research-status Report
  • [Presentation] EFFECT OF COMBINAION OF PROTEINS ON FRICTIONAL PROPERTY FOR JOINT PROSTHESIS MATERIALS2017

    • Author(s)
      K. Nakashima, S. Kudo, Y. Sawae, T. Murakami
    • Organizer
      Leeds-Lyon Symposium on Tribology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Friction and adsorption characteristics of albumin and globulin under friction condition2017

    • Author(s)
      Kazuhiro Nakashima, Yoshinori Sawae, Teruo Murakami
    • Organizer
      トライボロジー会議2017秋 高松
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2種の蛋白質混合溶液中における人工関節材料の摩擦特性2017

    • Author(s)
      中嶋 和弘,工藤 奨,澤江 義則,村上 輝夫
    • Organizer
      トライボロジー会議2017春東京
    • Related Report
      2017 Annual Research Report
  • [Presentation] CoCrMo合金上の蛋白質吸着膜の摩擦特性の荷重依存性2016

    • Author(s)
      中井 勝也, 中嶋 和弘, Susumu Kudo, 澤江 義則, 村上 輝夫
    • Organizer
      トライボロジー会議2016 秋 新潟
    • Place of Presentation
      新潟県
    • Year and Date
      2016-10-12
    • Related Report
      2016 Research-status Report
  • [Presentation] The effect of contact pressure on tribological characteristics of protein film adsorbed on CoCrMo alloy2016

    • Author(s)
      Kazuhiro Nakashima, Susumu Kudo, Yoshinori Sawae, Teruo Murakami
    • Organizer
      3rd International Conference on Bio Tribology
    • Place of Presentation
      London, UK
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of protein adsorption on friction of metal/UHMWPE sliding pair2016

    • Author(s)
      Kazuhiro Nakashima, David Necas, Yoshinori Sawae, T. Fujisawa, Takehiro Morita, Tetsuo Yamaguchi, M. Vrbka, I. Krupka, M. Hartl
    • Organizer
      3rd International Conference on Bio Tribology
    • Place of Presentation
      London, UK
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Superior biotribologycal properties of poly(viny alcohol) hybrid hydrogel for artificial cartilage2016

    • Author(s)
      Kazuhiro Nakashima, Teruo Murakami, Seido Yarimitsu, Nobuo Sakai, Seji Omata, Saori Sasaki, Tetsuo Yamaguchi, Yoshinori Sawae, Atsushi Suzuki
    • Organizer
      3rd International Conference on Bio Tribology
    • Place of Presentation
      London, UK
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] FORMATION PROCESS OF PROTEIN FILM ADSORBED ON JOINT PROSTHESIS MATERIAL2016

    • Author(s)
      Kazuhiro Nakashima, Susumu Kudo, Yoshinori Sawae, Teruo Murakami
    • Organizer
      4th Malaysia-Japan Tribology Symposium
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 人工関節材料に吸着した蛋白質膜のせん断強さ評価2015

    • Author(s)
      中嶋和弘,澤江義則,工藤奨,村上輝夫
    • Organizer
      第42回臨床バイオメカニクス学会
    • Place of Presentation
      東京都 千代田区
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Behavior of Protein Film Adsorbed on Joint Prosthesis Material under Rubbing2015

    • Author(s)
      Nakashima K, Sawae Y, Kudo S, Murakami T
    • Organizer
      The 8th International Biotribology Forum and The 36th Biotribology Symposium
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-09-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Investigation of Adsorption and Desorption Behavior of Protein Film on Joint Prosthesis Material under Rubbing Condition2015

    • Author(s)
      K.Nakashima, A. Yoshida, S. Kudo, Y. Sawae and T. Murakami
    • Organizer
      ITC Tokyo 2015
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 人工関節材料の摩擦摩耗特性へ影響する蛋白質吸着膜の観察2015

    • Author(s)
      中嶋 和弘  澤江 義則 )工藤 奨  村上 輝夫
    • Organizer
      トライボロジー会議 2015 春 姫路
    • Place of Presentation
      兵庫県 姫路市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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