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Development of non-contactl measurment for ultrasonic contrast agent and its application to molecular imaging

Research Project

Project/Area Number 15K06104
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Measurement engineering
Research InstitutionChiba University

Principal Investigator

Yoshida Kenji  千葉大学, フロンティア医工学センター, 助教 (10572985)

Co-Investigator(Kenkyū-buntansha) 渡辺 好章  同志社大学, 生命医科学部, 教授 (60148377)
Research Collaborator YAMAGUCHI Tadashi  千葉大学, フロンティア医工学センター, 教授 (40334172)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsマイクロバブル / 超音波 / 造影剤 / 減衰係数 / 後方散乱係数 / 圧電共振子 / 分子イメージング / 非線形振動 / 超音波分子イメージング / 数密度推定 / シェルの粘弾性 / 圧電センサ / 音波減衰 / シェル
Outline of Final Research Achievements

In order to increase the quantitative performance of ultrasonic molecular imaging, the method to estimate the number density of contrast agents was proposed and the evaluation system was constructed to verify the performance of proposed method. The transducer for pulse-echo method was incorporated into the evaluation system beased on quartz crystal microbalance for the verification. Using the evaluation system, the interaction between avidin as target molecule and biotinylated bubbles as contrast agents was monitored by pulse echo method. As a result, we succeeded in detecting the interaction by analysis of the echo signal. In addition, we developed the evaluation system into more stable one by using flow cell where the liquid was automatically sent.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] ストラスブール大学(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ストラスブール大学(フランス)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ストラスブール大学, フランス国立科学研究センター(フランス)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Area density of streptavidin can be evaluated by the number density of biotinylated microbubbles2017

    • Author(s)
      Yasuhiro Yokoi, Kenji Yoshida, Yuta Otsuki, Yoshiaki Watanabe
    • Journal Title

      Applied Physics Letters

      Volume: 110 Issue: 7

    • DOI

      10.1063/1.4975830

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Estimation of size and number density of microbubbles based on analysis of frequency-dependent attenuation2016

    • Author(s)
      Kenji Yoshida, Kazuki Tamura, Tadashi Yamaguchi
    • Journal Title

      Japanese Jornal of Applied Physics

      Volume: 未定

    • NAID

      210000146786

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 超音波照射下におけるポロキサマー膜をもつマイクロバブルの振動特性2018

    • Author(s)
      田畑拓、小山大介、松川真美、吉田憲司、 Krefft Marie-Pierre
    • Organizer
      日本音響学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 超音波分子イメージング用造影剤と標的分子の相互作用モニタリングシステムの構築2017

    • Author(s)
      横井康弘,吉田憲司,大月裕太,渡辺好章
    • Organizer
      日本音響学会
    • Place of Presentation
      明治大学(神奈川,川崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Experimental investigation on chemical kinetics between biotinylated microbubbles and streptavidin2017

    • Author(s)
      Yuta Otsuki, Kenji Yoshida, Yoshiaki Watanabe
    • Organizer
      IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ビオチン修飾バブルとストレプトアビジン間の化学反応における反応速度の解析2017

    • Author(s)
      大月裕太、吉田憲司、横井康弘、渡辺好章
    • Organizer
      第38回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of sensor system using quartz crystal microbalance for detecting nano- and microbubbles2016

    • Author(s)
      Kenji Yoshida, Yasuhiro Yokoi, Yoshiaki Watanabe
    • Organizer
      The 37th Symposium on UltraSonic Electronics
    • Place of Presentation
      Busan (Korea)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Estimation of size and number density of microbubbles under irradiation of finite-amplitude ultrasound2016

    • Author(s)
      Kenji Yoshida, Kazuki Tamura, Tadashi Yamaguchi
    • Organizer
      IEEE International Ultrasonics Symposium 2016
    • Place of Presentation
      Tours (France)
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement of concentration of molecule by evaluating the number density of targeted microbubble2016

    • Author(s)
      Yasuhiro Yokoi, Kenji Yoshida, Ryosuke Shimoya, Yoshiaki Watanabe
    • Organizer
      IEEE International Ultrasonics Symposium 2016
    • Place of Presentation
      Tours (France)
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 有限振幅音波照射時の超音波診断用造影剤のサイズ・密度推定2016

    • Author(s)
      吉田憲司、田村和輝、山口匡
    • Organizer
      日本音響学会
    • Place of Presentation
      桐蔭横浜大学(神奈川県、横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] レーザドップラ振動計を用いた超音波照射下における Pluronic F68 マイクロバブルの振動計測2016

    • Author(s)
      安藤 優,西村 ジュン,谷村 望美,香川 幸大,田畑 拓,吉田 憲司,小山 大介,渡邊 好章,Krafft Marie Pierre
    • Organizer
      日本音響学会
    • Place of Presentation
      桐蔭横浜大学(神奈川県、横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 低流速定常流における気泡懸濁液の減衰,後方散乱係数の測定2015

    • Author(s)
      吉田憲司、田村和輝、山口匡
    • Organizer
      超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県、つくば市)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] The evaluation system for measuring sensitivity of microbubbles to target molecules using a quartz crystal microbalance2015

    • Author(s)
      Yasuhiro Yokoi, Kenji Yoshida, Ryosuke Shimoya, Yoshiaki Watanabe
    • Organizer
      IEEE International Ultrasonics Symposium 2015
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 水晶振動子を用いた分子標的超音波造影剤の感度評価法の提案2015

    • Author(s)
      横井康弘, 吉田憲司, 下谷遼資, 渡辺好章
    • Organizer
      日本音響学会
    • Place of Presentation
      会津大学(福島県、会津若松市)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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