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Development of monitoring system of oxygenated hemoglobin supply to fetus and placenta based on propagation of light and acoustic wave

Research Project

Project/Area Number 15K06125
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Measurement engineering
Research InstitutionNational Defense Medical College

Principal Investigator

Okawa Shinpei  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医用工学, 助教 (20432049)

Co-Investigator(Kenkyū-buntansha) 藤井 宏之  北海道大学, 工学研究院, 助教 (00632580)
平沢 壮  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医用工学, 助教 (60583086)
Research Collaborator SEI Kiguna  防衛医科大学校, 医学研究科
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords光音響 / 光音響イメージング / 医用工学 / 計測工学 / 信号処理 / 画像再構成 / 逆問題
Outline of Final Research Achievements

To develop the method to monitor the oxygenated hemoglobin supply to fetus and placenta by using photoacoustic wave which is the ultrasound induced by the pulsed laser light, the estimation of the tissue optical properties such as scattering and absorption coefficients from measured photoacoustic wave, the development of the images reconstruction for quantitative photoacoustic tomography, and the photoacoustic imaging of the placenta of rabbits were conducted.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 4 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] Numerical and experimental investigations of dependence of photoacoustic signals from gold nanoparticles on the optical properties2018

    • Author(s)
      Okawa, S., Hirasawa, T., Sato, R., Kushibiki, T., Ishihara, M. and Teranishi, T.
    • Journal Title

      Optical Review

      Volume: Online first Issue: 3 Pages: 1-6

    • DOI

      10.1007/s10043-018-0435-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3D quantitative photoacoustic image reconstruction using Monte Carlo method and linearization2018

    • Author(s)
      Shinpei Okawa,Takeshi Hirasawa,Kazuhiro Tsujita*,Toshihiro Kushibiki,Miya Ishihara
    • Journal Title

      Proceedings of SPIE

      Volume: 10494 Pages: 172-172

    • DOI

      10.1117/12.2293229

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the approximations of light propagation on quantitative photoacoustic tomography using two-dimensional photon diffusion equation and linearization2017

    • Author(s)
      Shinpei Okawa,Takeshi Hirasawa,Toshihiro Kushibiki,Miya Ishihara
    • Journal Title

      Optical Review

      Volume: 24(6) Issue: 6 Pages: 705-726

    • DOI

      10.1007/s10043-017-0369-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 光音響シミュレーションと定量的トモグラフィー画像再構成-光音響を用いたより高度な診断を目指して-2017

    • Author(s)
      大川晋平, 平沢 壮, 佐藤良太,櫛引俊宏, 石原美弥,寺西利治
    • Journal Title

      OPTRONICS

      Volume: 36 Pages: 66-71

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Next-Generation Biomedical Imaging with Near Infrared Light: Diffuse Optical, Fluorescence, and Photoacoustic Tomography2017

    • Author(s)
      大川晋平, 石原美弥, 西村吾朗, 星 詳子
    • Journal Title

      Journal of The Society of Instrument and Control Engineers

      Volume: 56 Issue: 11 Pages: 863-868

    • DOI

      10.11499/sicejl.56.863

    • NAID

      130006206074

    • ISSN
      0453-4662, 1883-8170
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo photoacoustic imaging of uterine cervical lesion and its image processing based on light propagation in biological medium2017

    • Author(s)
      Okawa, S., Sei, K., Hirasawa, T., Irisawa, K., Hirota, K., Wada, T., Kushibiki, T., Furuya, K., Ishihara, M.
    • Journal Title

      Proceedings of SPIE

      Volume: 10064 Pages: 100642S-100642S

    • DOI

      10.1117/12.2253716

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Spatial filtered reconstruction for changes in the absorption coefficient for diffuse optical tomography2016

    • Author(s)
      Okawa, S.
    • Journal Title

      Proceedings of SICE Annual Conference 2016

      Volume: 2016 Pages: 1160-1163

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Renormalization of the highly forward-peaked phase function using the double exponential formula for radiative transfer2016

    • Author(s)
      Fujii, H., Okawa, S., Yamada, Y., Hoshi, Y., Watanabe, M.
    • Journal Title

      Journal of Mathematical Chemistry

      Volume: 54 Issue: 10 Pages: 2048-2061

    • DOI

      10.1007/s10910-016-0670-3

    • NAID

      120006360048

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of the optical properties of gold nanoparticles on photoacoustic signals2016

    • Author(s)
      Shinpei Okawa, Takeshi Hirasawa, Ryota Sato, Toshihiro Kushibiki, Miya Ishihara, Toshiharu Teranishi
    • Journal Title

      Proceedings of SPIE

      Volume: 9708 Pages: 970836-970836

    • DOI

      10.1117/12.2213879

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Numerical and experimental studies on quantification of the optical properties by use of photoacoustic measurement2016

    • Author(s)
      Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
    • Journal Title

      マス・フォア・インダストリ研究 Mathematical Background and Future Progress of Practical Inverse Problems

      Volume: 5 Pages: 81-109

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] モンテカルロ法による光伝播計算を用いた定量的光音響画像再構成2018

    • Author(s)
      大川晋平, 平沢 壮, 辻田和宏, 櫛引俊宏, 石原美弥
    • Organizer
      電気学会 光・量子デバイス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Trial for a new fetal assessment by ultrasound-guided photoacoustic measurement of placental oxygen saturation2018

    • Author(s)
      Sei、K. , Sasa, H., Furuya, K.,
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Noninvasive photoacoustic imaging using microconvex probe2017

    • Author(s)
      Okawa, S., Sei, K., Shinchi, M., Nakamura, A., Hirasawa, T., Tsuda, H., Wada, T., Horiguchi, A., Kushibiki, T., Sasa, H., Furuya, K., Asano, T., and Ishihara, M.
    • Organizer
      the 94th Annual Meeting of Physiological Society of Japan
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 生体内光伝播計算を用いた定量的3次元光音響トモグラフィー2017

    • Author(s)
      大川晋平,平沢 壮,辻田和宏,櫛引俊宏,石原美弥
    • Organizer
      第38回日本レーザー医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Quantitative photoacoustic image reconstruction with linearization and l1-norm minimization2017

    • Author(s)
      Okawa, S.
    • Organizer
      Inverse problems and medical imaging
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 光音響技術を用いた胎盤内血液酸素飽和度計測~胎児超音波診断における新しい定量的指標の可能性~2017

    • Author(s)
      精きぐな, 平沢 壮, 大川晋平, 笹 秀典, 古谷健一, 石原美弥
    • Organizer
      第40回日本母体胎児学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Approximations in quantitative photoacoustic tomography reconstructing the absorption coefficient2016

    • Author(s)
      Okawa, S., Hirasawa, T., Kushibiki, T., and Ishihara, M.
    • Organizer
      The 10th ICME International Conference on Complex Medical Engineering
    • Place of Presentation
      Utsunomiya, japan
    • Year and Date
      2016-08-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Fundamental studies on quantitative biomedical photoacoustic imaging2015

    • Author(s)
      Shinpei Okawa, Takeshi Hirasawa, Seishiro Tatsukawa, Sei Kiguna, Toshihiro Kushibiki, Miya Ishihara
    • Organizer
      2015 Taiwan-Japan Joint Workshop on Inverse Problems and the Related Topics
    • Place of Presentation
      台北
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical and experimental studies on quanti cation of the optical properties by use of photoacoustic measurement2015

    • Author(s)
      Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
    • Organizer
      九州大学 マス・フォア・インダストリ研究所 ワークショップ 実用逆問題の背景にある数理と新展開
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 光音響信号を用いた生体組織の光学特性値推定2015

    • Author(s)
      立川誠四郎, 大川 晋平, 精 きぐな, 平沢 壮, 櫛引 俊宏, 藤田 真敬, 石原 美弥
    • Organizer
      日本光学会年次学術講演会Optics & Photonics Japan 2015
    • Place of Presentation
      東京
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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