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One-step fabrication of high-adhesive Ag-containing hydroxyapatite coating on titanium substrate

Research Project

Project/Area Number 15K06452
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Composite materials/Surface and interface engineering
Research InstitutionKitami Institute of Technology

Principal Investigator

Ohtsu Naofumi  北見工業大学, 工学部, 准教授 (10400409)

Co-Investigator(Renkei-kenkyūsha) ARAI Hirofumi  北見工業大学, 工学部, 准教授 (70295848)
SUMISA Futoshi  オホーツク食品加工技術センター, 研究員 (50523742)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsチタンインプラント / 化学的表面処理 / Ag/HAp被膜 / 骨組織適合性 / 抗菌性 / 難剥離性 / チタン製インプラント / 硬組織適合性 / 表面処理 / Ag含有アパタイト被膜 / アパタイト被膜 / 銀 / 銀含有アパタイト被膜 / 骨伝導性 / スラリー処理
Outline of Final Research Achievements

The research project developped a new surface treatment process for fabricating Ag-contained hydroxyapatite layer on titanium implant and demonstrated that the new process enables to reduce the risks for surgical operation of artificial joint replacement. The coating fabricated by the new process is expected to have high-adhesive strength and furthermore, facilitatie osteogenesis around the implant. In addition, the coated-implant showed an excellent antibacterial efficcacy due to Ag-release from the coating although the release did not show cytotoxicity. The research project demonstrate that the new surface modification process can provide a high-performance titanium medical implant with a low cost.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Comparison of NiTi alloy surfaces formed by anodization in nitric, phosphoric, and sulfuric acid electrolytes2018

    • Author(s)
      Ohtsu Naofumi、Hirano Yuma、Takiguchi Koudai
    • Journal Title

      Surface and Coatings Technology

      Volume: 335 Pages: 306-313

    • DOI

      10.1016/j.surfcoat.2017.12.050

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Antibacterial effect of zinc oxide/hydroxyapatite coatings prepared by chemical solution deposition2018

    • Author(s)
      Ohtsu Naofumi、Kakuchi Yuko、Ohtsuki Tsubasa
    • Journal Title

      Applied Surface Science

      Volume: 445 Pages: 596-600

    • DOI

      10.1016/j.apsusc.2017.09.101

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Growth of oxide layers on NiTi alloy surfaces through anodization in nitric acid electrolyte2017

    • Author(s)
      Ohtsu Naofumi、Hirano Yuma
    • Journal Title

      Surface and Coatings Technology

      Volume: 325 Pages: 75-80

    • DOI

      10.1016/j.surfcoat.2017.06.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface chemistry and osteoblast-like cell response on a titanium surface modified by a focused Nd:YAG laser2017

    • Author(s)
      N. Ohtsu, T. Kozuka, M. Yamane, H. Arai
    • Journal Title

      Surface and Coatings Technology

      Volume: 309 Pages: 220-226

    • DOI

      10.1016/j.surfcoat.2016.10.024

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Analytical Procedure for the Accurate Determination of Ag, Cu and Ni in a Phosphate Buffered Saline Solution Using GF-AAS2016

    • Author(s)
      平野雄馬、大島裕樹、小俣雅嗣、大津直史
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 65 Issue: 8 Pages: 457-463

    • DOI

      10.2116/bunsekikagaku.65.457

    • NAID

      130006846981

    • ISSN
      0525-1931
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] スラリー埋没加熱処理で形成したAg含有アパタイト複合酸化被膜の疑似体液浸漬による微細組織変化2017

    • Author(s)
      友澤方成、二村寛子、山下慎平、大津直史
    • Organizer
      日本金属学会2017年春季講演大会
    • Place of Presentation
      首都大学東京南大沢キャンパス
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] スラリー埋没加熱処理アパタイト被膜チタン材料上における骨芽細胞の石灰化2017

    • Author(s)
      山下慎平、大津直史
    • Organizer
      日本金属学会2017年春季講演大会
    • Place of Presentation
      首都大学東京南大沢キャンパス
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] スラリー埋没加熱処理を用いたZr材料への骨親和性付与2017

    • Author(s)
      横岩佑城、大津直史
    • Organizer
      日本金属学会2017年春季講演大会
    • Place of Presentation
      首都大学東京南大沢キャンパス
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Antibacterial hydroxyapatite coating on titanium via a simple chemical treatment process using calcium phosphate slurry2017

    • Author(s)
      N. Ohtsu, Y. Kakuchi, Y. Yoshida
    • Organizer
      18th International Union of Materials Research Society - International COnference in Asia
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Calcium-phosphate slurry processing:a novel chemical treatment technique to activate osteogenesis on titanium2016

    • Author(s)
      N. Ohtsu
    • Organizer
      World Biomaterials congress 2016
    • Place of Presentation
      モントリオール(カナダ国)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] Antibacterial behaviors of Ag-contained apatite coating on titanium substrate fabricated using calcium-phosphate slurr2015

    • Author(s)
      Y. Kakuchi, N. Ohtsu
    • Organizer
      PacifiChem 2015
    • Place of Presentation
      ハワイ、ホノルル
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] スラリー埋没加熱処理で形成したAg含有アパタイト酸化被膜の異なる菌種に対する抗菌持続性2015

    • Author(s)
      角地優子、大津直史
    • Organizer
      日本金属学会秋季大会
    • Place of Presentation
      九州大学
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Ag含有アパタイト被膜の生体模擬環境下における抗菌性能評価2015

    • Author(s)
      角地優子、大津直史
    • Organizer
      九州分析化学若手の会 夏季セミナー
    • Place of Presentation
      熊本県上天草市
    • Year and Date
      2015-07-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Ag含有アパタイト被膜の生体模擬環境下における抗菌持続性評価,2015

    • Author(s)
      角地優子、大津直史
    • Organizer
      北海道分析化学会緑陰セミナー
    • Place of Presentation
      北海道河東郡音更町
    • Year and Date
      2015-06-27
    • Related Report
      2015 Research-status Report
  • [Remarks] 研究室webページ

    • URL

      http://www.mtrl.kitami-it.ac.jp/~ohtsu/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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