Development of next generation bioactive titanium

• Project/Area Number: 15K06482
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Structural/Functional materials
• Research Institution: Kyoto University
• Principal Investigator: Fujibayashi Shunsuke 京都大学, 医学研究科, 特定教授 (30362502)
• Co-Investigator(Renkei-kenkyūsha): YAMAGUCHI Seiji 中部大学, 生命健康科学部, 講師 (50726198)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生体活性チタン / ストロンチウム / マグネシウム / 骨芽細胞 / チタン金属 / ストロンチウムイオン / マグネシウムイオン / 骨形成促進

Outline of Final Research Achievements

Bioactive titanium metals induced strontium ions or magnesium ions enhanced expression of integrin β1 and osteogenic differentiation in in vitro studies using MC3T3-E1 cells. In rabbit in vivo studies, they also provided greater biomechanical strength between bone and bioactive titanium metals. Because induced strontium ions were detected in the bone near the implant, strontium ions were released and influenced the bone near the implant.

Research Products

• [Journal Article] Strontium and Magnesium ions released from bioactive titanium metal promote early bone bonding in a rabbit implant model (2017)
  • Author(s): Yaichiro Okuzu, Shunsuke Fujibayashi, Seiji Yamaguchi, Koji Yamamoto, Takayoshi Shimizu, Takashi Sono, Koji Goto, Bungo Otsuki, Tomiharu Matsushita, Tadashi Kokubo, Shuichi Matsuda
  • Journal Title: Acta Biomaterialia Volume: 63 Pages: 383-392
  • DOI: 10.1016/j.actbio.2017.09.019
  • Peer Reviewed
• [Presentation] Bioactivity of titanium metal releasing strontium ions or magnesium ions. (2017)
  • Author(s): Yaichiro Okuzu, Shunsuke Fujibayashi, Seiji Yamaguchi, Koji Yamamoto, Koji Goto, Bungo Otuski, Tomiharu Matsushita, Tadashi Kokubo, Shuichi Matsuda.
  • Organizer: Orthopaedic Research Society Annual Meeting 2017
  • Place of Presentation: San Diego Convention Center、San Diego（USA）
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] Bioactivity of titanium metal releasing strontium ions or magnesium ions (2017)
  • Author(s): Yaichiro Okuzu, Shunsuke Fujibayashi, Seiji Yamaguchi, Koji Yamamoto, Koji Goto, Bungo Otsuki, Tomiharu Matsushita, Tadashi Kokubo, Shuichi Matsuda.
  • Organizer: Annual Meeting of the Orthopaedic Research Society
  • Int'l Joint Research
• [Presentation] 骨形成促進イオン徐放性チタン金属の生体活性能の評価 (2015)
  • Author(s): 奥津弥一郎, 藤林俊介, 後藤公志, 大槻文悟, 山本浩司, 山口誠二, 松下富春, 小久保正, 松田秀一
  • Organizer: 第35回整形外科バイオマテリアル研究会
  • Place of Presentation: ソラシティカンファレンスセンター（東京千代田区）
  • Year and Date: 2015-12-12
• [Presentation] SrイオンやMgイオンを徐放するチタン金属の生体活性能の評価 (2015)
  • Author(s): 奥津弥一郎, 藤林俊介, 後藤公志, 大槻文悟, 山本浩司, 山口誠二, 松下富春, 小久保正, 松田秀一
  • Organizer: 第37回日本バイオマテリアル学会大会
  • Place of Presentation: 京都テルサ（京都府京都市）
  • Year and Date: 2015-11-09
• [Presentation] SrイオンやMgイオンを徐放するチタン金属の生体活性能の評価 (2015)
  • Author(s): 奥津弥一郎, 藤林俊介, 後藤公志, 大槻文悟, 山本浩司, 山口誠二, 松下富春, 小久保正, 松田秀一.
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場（富山県富山市）
  • Year and Date: 2015-10-22
• [Presentation] SrイオンやMgイオンを徐放するチタン金属の生体活性能の評価 (2015)
  • Author(s): 奥津弥一郎, 藤林俊介, 後藤公志, 大槻文悟, 山本浩司, 山口誠二, 松下富春, 小久保正, 松田秀一
  • Organizer: 日本バイオマテリアル学会第10回関西若手研究発表会
  • Place of Presentation: 関西大学（大阪府吹田市）
  • Year and Date: 2015-08-05