Development of new aortic stent-graft materials by plasma technology that can control the surface morphology and the drug elution
Project/Area Number |
15K06492
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Structural/Functional materials
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Research Institution | Tokai University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
鈴木 哲也 慶應義塾大学, 理工学部(矢上), 教授 (10286635)
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Co-Investigator(Renkei-kenkyūsha) |
HOTTA Atsushi 慶應義塾大学, 理工学部, 教授 (30407142)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | DLC / ポリマー / 薬剤徐放 / ナノファイバー / 細胞 / 組織工学 / カバードステント / 細胞増殖因子 / ナノファイバ― / ダイヤモンドライクカーボン / リン脂質ポリマー / 新機能材料 |
Outline of Final Research Achievements |
Endovascular aneurysm repair (EVAR) using a stent-graft is designed to help prevent an aneurysm from bursting. Endoleaks are characterized by persistent blood flow within the aneurysm sac following EVAR. In this study, to inhibit the endoleak inflow, we can controll the surface morphology and the drug elution of graft material by plasma technology, and we developed new materials for a graft fabric that enhanced cell adhesion and proliferation. As the specific results, we revealed that (1) the control of the surface morphology and the drug elution contributed to the proliferation of endothelial cells and that (2) micro-patterned hydrogenated amorphous carbon (a-C:H) coating on the polymer impregnated with basic fibroblast glows factor (bFGF) improved the endothelial cells growth rate.
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Report
(4 results)
Research Products
(111 results)
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[Journal Article] Prospective multi-center registry to evaluate efficacy and safety of the newly developed diamond-like carbon-coated cobalt-chromium coronary stent system.2016
Author(s)
K. Ando, K. Ishii, E. Tada, K. Kataoka, A. Hirohata, K. Goto, K. Kobayashi, H. Tsutsui, M. Nakahama, H. Nakashima, S. Uchikawa, J. Kanda, S. Yasuda, J. Yajima, H. Kitabayashi, S. Sakurai, K. Nakanishi, N. Inoue, H. Noike, T. Hasebe, T. Sato, M. Yamasaki, T. Kimura,
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Journal Title
Cardiovascular Intervention and Therapeutics
Volume: online
Issue: 3
Pages: 1-8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Perirenal lymphatic systems: Evaluation using spectral presaturation with inversion recovery T2 -weighted MR images with 3D volume isotropic turbo spin-echo acquisition at 3.0T.2016
Author(s)
S. Matsumoto, H. Mori, M. Kiyonaga, Y. Yamada, R. Takaji, F. Sato, H. Mimata, N. Hijiya, M. Moriyama, R. Tanoue , K. Tomonari, T. Matsumoto, T. Hasebe.
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Journal Title
Journal of Magnetic Resonance Imaging
Volume: 44
Pages: 897-905
Related Report
Peer Reviewed
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[Journal Article] MRI-TRUS融合画像リアルタイムガイド下経会陰式前立腺標的狙撃生検による前立腺癌診断の有用性に関する検討2015
Author(s)
小路直, 平岩真一郎, 橋本亜樹生, 日暮太朗, 川上正能, 朝長哲朗, 中野まゆら, 花井一也, 橋田和靖, 遠藤じゅん, 長谷部光泉, 田尻琢磨, 寺地敏郎, 内田豊昭
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Journal Title
Japanese Journal of Endourology
Volume: 28
Pages: 308-316
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 腰仙移行部の化膿性脊椎炎に対するCTガイド下経仙骨椎間腔膿瘍ドレナージ2016
Author(s)
松本知博, 嶺貴彦, 橋田和靖, 遠藤じゅん, 仁科良, 峠田昌子, 壁谷悠介, 鴨野真弘, 蘇原映碩, 檜垣惠, 長谷部光泉
Organizer
第45回 日本IVR学会総会
Place of Presentation
ウェスティンナゴヤキャッスル(愛知県名古屋市)
Year and Date
2016-05-26
Related Report
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[Presentation] 医工産学連携による血管内治療デバイスの開発2015
Author(s)
長谷部光泉, 松本知博, 嶺貴彦,堀田篤, 鈴木哲也
Organizer
平成27年度新規事業「ものづくり中小企業・小規模事業者連携支援事業」 第6回連携クラスターサロン
Place of Presentation
西武信用金庫八王子支店(東京都八王子市)
Year and Date
2015-12-02
Related Report
Invited
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[Presentation] 胸部IVRの最新トレンド2015
Author(s)
松本知博,嶺貴彦,長谷部光泉
Organizer
複十字病院 第6回呼吸器画像セミナー
Place of Presentation
財団法人結核予防会複十字病院(東京都清瀬市)
Year and Date
2015-11-17
Related Report
Invited
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[Presentation] 炭素系ナノ薄膜コーティングステント2015
Author(s)
長谷部光泉,松本知博,嶺貴彦,堀田篤,鈴木哲也
Organizer
バイオトロニックジャパンセミナー
Place of Presentation
恵比寿ビジネスタワー(東京都渋谷区)
Year and Date
2015-10-14
Related Report
Invited
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[Presentation] 門脈血栓症治療後に再灌流症候群を起こした1例2015
Author(s)
伊藤裕幸, 水上創, 永田順子, 小嶋清一郎, 高清水眞二, 渡辺勲史, 松本知博, 長谷部光泉, 幕内博康
Organizer
第22回日本門脈圧亢進症学会総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-09-10
Related Report
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[Presentation] 肝内門脈大循環シャント(IPSVS)に対して、経回結腸静脈閉塞術(TIO)を施行し、肝性脳症の改善をみた特発性門脈圧亢進症の1例2015
Author(s)
小嶋清一郎, 伊藤裕幸, 高清水眞二, 白井孝之, 市川仁志, 永田順子, 水上創, 野村栄治, 幕内博康, 松本知博, 長谷部光泉, 田尻琢磨, 渡辺勲史
Organizer
第22回日本門脈圧亢進症学会総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-09-10
Related Report
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[Presentation] DEB-TACEの基礎知識2015
Author(s)
長谷部光泉,松本知博,嶺貴彦,渡辺勲史
Organizer
第22回日本門脈圧亢進症学会総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-09-10
Related Report
Invited
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[Presentation] B-TACE2015
Author(s)
松本知博,嶺貴彦,長谷部光泉
Organizer
第3回IVR同志会
Place of Presentation
ホテル ザ・エルシィ町田(東京都町田市)
Year and Date
2015-08-29
Related Report
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[Presentation] EVAR related intervention2015
Author(s)
Hasebe T, Matsumto T, Mine T
Organizer
Interventional Oncology Workshop in Bankok
Place of Presentation
King Chulalongkorn Memorial Hospital, Chulalongkorn University(Thailand)
Year and Date
2015-07-02
Related Report
Invited
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[Presentation] Balloon-occluded arterial stump pressure (BOASP) at each hepatic arterial level2015
Author(s)
Matsumoto T, Endo J, Hashida K, Mizukami H, Nagata J, Ichikawa H, Kojima S, Takashimizu S, Watanabe N, Hasebe T
Organizer
The 44th Annual Meeting of the Japanese Society of Interventional Radiology, The 12th International Symposium of Interventional Radiology, The 4th Asia Pacific Conference on Interventional Oncology
Place of Presentation
Seagaia Convention Center(Japan)
Year and Date
2015-05-28
Related Report
Int'l Joint Research
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[Presentation] Carbon-based materials for medical applications2015
Author(s)
Hasebe T, Matsumoto T, Yamato Y, Bito K, Maegawa S, Mine T, Hotta A, Suzuki T
Organizer
The 9th International Conference on New Diamond and Nano Carbons 2015 (NDNC2015)
Place of Presentation
Shizuoka GRANSHIP(Japan)
Year and Date
2015-05-27
Related Report
Int'l Joint Research / Invited
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