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Scale-up support technology for newly developed products using existing production data

Research Project

Project/Area Number 15K06554
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Reaction engineering/Process system
Research InstitutionKyoto University

Principal Investigator

Kano Manabu  京都大学, 情報学研究科, 教授 (30263114)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsスケールアップ / ベイズ的最適化 / 転移学習 / 製剤 / ガウス過程回帰 / 操業条件最適化 / ソフトセンサー / 仮想計測 / 変数重要度 / 因果推論
Outline of Final Research Achievements

We aim to develop a new method that can optimize operating conditions of commercial-scale equipment to achieve scale-up from pilot-scale equipment even when only a small number of experiments can be performed with commercial-scale equipment. The proposed method, combined task Bayesian optimization (CTBO), uses not only data of a target task, e.g., a commercial-scale plant, but also data of a source task, e.g., a pilot-scale plant. CTBO determines new operating conditions in the target task sequentially by BO while information of the source task is exploited by transfer learning. CTBO was compared with BO and LW-PLS + jDE (locally weighted partial least squares + self-adaptive differential evolution) through their applications to a pharmaceutical granulation process. CTBO remarkably outperformed the other methods. CTBO is expected to be useful not only for scale-up but also for technology transfer.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016

All Presentation (14 results) (of which Int'l Joint Research: 8 results)

  • [Presentation] 製造機器間差の小さい製造パラメータを用いた造粒中水分含量モニタリング手法2017

    • Author(s)
      柳沼啓太, 宮野拓也, 中川弘司, 渡部知行, 南秀実, 加納学
    • Organizer
      化学工学会年会
    • Place of Presentation
      芝浦工業大学
    • Year and Date
      2017-03-06
    • Related Report
      2016 Research-status Report
  • [Presentation] COMBINED TASK BAYESIAN OPTIMIZATION: A SMART SOLUTION TO SCALE-UP PROBLEM2017

    • Author(s)
      Ryosuke Yoshizaki, Manabu Kano
    • Organizer
      Foundations of Computer Aided Process Operations / Chemical Process Control
    • Place of Presentation
      Tucson, US
    • Year and Date
      2017-01-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Granger Causality Analysis of Non-time-series Data2017

    • Author(s)
      Ryosuke Sato, Manabu Kano
    • Organizer
      システム制御情報学会研究発表講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Non-time-series Kernel Granger Causality for Batch Processes2017

    • Author(s)
      Ryosuke Sato, Koichi Fujiwara, Manabu Kano
    • Organizer
      The 17th Congress, Asian Pacific Confederation of Chemical Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Causal Analysis based on Non-time-series Kernel Granger Causality in a Steelmaking Process2017

    • Author(s)
      Ryosuke Sato, Koichi Fujiwara, Masahiro Tani, Junichi Mori, Junji Ise, Kohhei Harada, Manabu Kano
    • Organizer
      Asian Control Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fault Identification with Modified Reconstruction-Based Contribution Based on Kernel Principal Component Analysis2017

    • Author(s)
      Koji Kitano, Manabu Kano, Bhushan Gopaluni
    • Organizer
      Asian Control Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combined Task Bayesian Optimization for Efficient Scale-up and Technology Transfer2016

    • Author(s)
      Ryosuke Yoshizaki, Manabu Kano
    • Organizer
      AIChE Annual Meeting
    • Place of Presentation
      San Francisco, US
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sparse Nonlinear Features Based Locally Weighted Kernel Partial Least Squares for Virtual Sensing of Nonlinear Time-Varying Processes2016

    • Author(s)
      Xinmin Zhang, Manabu Kano
    • Organizer
      AIChE Annual Meeting
    • Place of Presentation
      San Francisco, US
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 変数除去寄与による異常要因同定:酢酸ビニル製造プラントへの適用2016

    • Author(s)
      里山雄亮, 藤原幸一, 加納学
    • Organizer
      化学工学会秋季大会
    • Place of Presentation
      徳島大学
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Variable Elimination-based Fault Identification2016

    • Author(s)
      Yusuke Satoyama, Koichi Fujiwara, Manabu Kano
    • Organizer
      International Symposium on Design, Operation and Control of Chemical Processes
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sparse Sample Regression Based Just-In-Time Modeling (SSR-JIT): Beyond Locally Weighted Approach2016

    • Author(s)
      Taku Uchimaru, Manabu Kano
    • Organizer
      IFAC Symposium on Dynamics and Control of Process Systems, including Biosystems
    • Place of Presentation
      Trondheim, Norway
    • Year and Date
      2016-06-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 製造設備スケールアップ時のベイズ的操業条件最適化2016

    • Author(s)
      吉崎亮介,加納学
    • Organizer
      化学工学会年会
    • Place of Presentation
      関西大学( 大阪府吹田市 )
    • Year and Date
      2016-03-13
    • Related Report
      2015 Research-status Report
  • [Presentation] スパースサンプル回帰に基づくJust-In-Time モデリング2016

    • Author(s)
      内丸拓,加納学
    • Organizer
      化学工学会年会
    • Place of Presentation
      関西大学( 大阪府吹田市 )
    • Year and Date
      2016-03-13
    • Related Report
      2015 Research-status Report
  • [Presentation] ベイズ的最適化による製造設備スケールアップ時の操業条件決定2016

    • Author(s)
      吉崎亮介,加納学
    • Organizer
      計測自動制御学会制御部門マルチシンポジウム
    • Place of Presentation
      南山大学( 愛知県名古屋市 )
    • Year and Date
      2016-03-07
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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