• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Quantitative metabolomics methodology using stable isotope-labeled multi-compound cocktails

Research Project

Project/Area Number 15K06557
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Reaction engineering/Process system
Research InstitutionKyushu University

Principal Investigator

Izumi Yoshihiro  九州大学, 生体防御医学研究所, 准教授 (70622166)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords定量メタボロミクス / 定量リピドミクス / イオンクロマトグラフィー質量分析 / 超臨界流体クロマトグラフィー質量分析 / in vivoラベリング / in vitroラベリング / マトリックスエフェクト / 定量メタボローム分析 / イオンクロマトグラフィー / 超臨界流体クロマトグラフィー / 疾患メタボローム解析
Outline of Final Research Achievements

One of the current problems in metabolomics is the difficulty in integrating data collected on different days, using different equipment and/or facilities. Accordingly, the development of a fundamental methodology that enables quantitative comparison of large scale data is needed for next-generation metabolomics study. In the present study, we established quantitative metabolomics and lipidomics methodologies based on chromatography mass spectrometry and stable isotope-labeled multi-compound cocktails. The quantitative analytical system developed is a potentially useful tool for the integration or sharing of global metabolomics data.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (81 results)

All 2018 2017 2016 2015 Other

All Journal Article (20 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (52 results) (of which Int'l Joint Research: 17 results,  Invited: 15 results) Book (4 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits).2018

    • Author(s)
      Tamura S, Koike Y, Takeda H, Koike T, Izumi Y, Nagasaka R, Tsunoda T, Tori M, Ogawa K, Bamba T, Shiomi M.
    • Journal Title

      Eur. J. Pharmacol.

      Volume: 822 Pages: 147-153

    • DOI

      10.1016/j.ejphar.2018.01.013

    • NAID

      120006599147

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in docosahexaenoic acid-related lipid cascades in inflammatory bowel disease model mice.2018

    • Author(s)
      Nishiumi S, Izumi Y, *Yoshida M.
    • Journal Title

      Dig. Dis. Sci.

      Volume: 印刷中 Issue: 6 Pages: 1485-1496

    • DOI

      10.1007/s10620-018-5025-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release.2018

    • Author(s)
      Obata Y, Kita S, Koyama Y, Fukuda S, Takeda H, Takahashi M, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nakamura Y, Nishizawa H, Funahashi T, Ranscht B, Izumi Y, Bamba T, Fukusaki E, Hanayama R, Shimada S, Maeda N, Shimomura I.
    • Journal Title

      JCI Insight

      Volume: 3(8) Issue: 8 Pages: 1-18

    • DOI

      10.1172/jci.insight.99680

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Widely-targeted quantitative lipidomics methodology by supercritical fluid chromatography coupled with fast-scanning triple quadrupole mass spectrometry.2018

    • Author(s)
      Takeda H, Izumi Y, Takahashi M, Paxton T, Tamura S, Koike T, Yu Y, Kato N, Nagase K, Shiomi M, Bamba T.
    • Journal Title

      J. Lipid Res.

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of optimizing chromatographic conditions and mass spectrometric parameters for supercritical fluid chromatography/mass spectrometry.2017

    • Author(s)
      Fujito Y, Hayakawa Y, Izumi Y, Bamba T.
    • Journal Title

      J. Chromatogr. A

      Volume: 1508 Pages: 138-147

    • DOI

      10.1016/j.chroma.2017.05.071

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic engineering of oleaginous fungus Mortierella alpina for high production of oleic and linoleic acids2017

    • Author(s)
      Sakamoto Takaiku、Sakuradani Eiji、Okuda Tomoyo、Kikukawa Hiroshi、Ando Akinori、Kishino Shigenobu、Izumi Yoshihiro、Bamba Takeshi、Shima Jun、Ogawa Jun
    • Journal Title

      Bioresource Technology

      Volume: 245 Pages: 1610-1615

    • DOI

      10.1016/j.biortech.2017.06.089

    • NAID

      120006763922

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Harmonizing Lipidomics: NIST Interlaboratory Comparison Exercise for Lipidomics using Standard Reference Material 1950-Metabolites in Frozen Human Plasma.2017

    • Author(s)
      Bowde J A, Heckert A, Ulmer C Z, Jones C M, Koelmel J P, Izumi Y et a.
    • Journal Title

      J. Lipid Res.

      Volume: 58(12) Issue: 12 Pages: 2275-2288

    • DOI

      10.1194/jlr.m079012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydrophilic Metabolite Analysis2017

    • Author(s)
      平山明由,和泉自泰,松田史生,石川貴正,杉浦悠毅,鈴木隆弘
    • Journal Title

      Journal of the Mass Spectrometry Society of Japan

      Volume: 65 Issue: 5 Pages: 195-198

    • DOI

      10.5702/massspec.S17-47

    • NAID

      130007342684

    • ISSN
      1340-8097, 1880-4225, 1884-3271
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Lipoprotein profiling methodology based on determination of apolipoprotein concentration.2017

    • Author(s)
      Takeda H, Izumi Y, Tomita A, Koike T, Shiomi M, Fukusaki E, Matsuda F, Bamba T.
    • Journal Title

      Bioanalysis

      Volume: 9(1) Issue: 1 Pages: 9-19

    • DOI

      10.4155/bio-2016-0234

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation.2017

    • Author(s)
      Minami S, Yamamoto T, Takabatake Y, Takahashi A, Namba T, Matsuda J, Kimura T, Kaimori J, Matsui I, Takeda H, Takahashi M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Isaka Y.
    • Journal Title

      Autophagy

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity2017

    • Author(s)
      Masahiro Nagata, Yoshihiro Izumi, Eri Ishikawa, Ryoko Kiyotake, Rieko Doi, Satoru Iwai, Zakaria Omahdi, Toshiyuki Yamaji, Tomofumi Miyamoto, Takeshi Bamba, Sho Yamasaki
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 114 Issue: 16

    • DOI

      10.1073/pnas.1618133114

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The use of on-line SFE-SFC/MS/MS to analyze disease biomarkers in dried serum spots compared with serum analysis using LC/MS/MS. Rapid Communications in Mass Spectrometry2017

    • Author(s)
      Suzuki M., Nishiumi S., Kobayashi T., Sakai A., Iwata Y., Uchikata T., Izumi Y., Azuma T., Bamba T., Yoshida M.
    • Journal Title

      Rapid Communications in Mass Spectrometry

      Volume: 31 Issue: 10 Pages: 886-984

    • DOI

      10.1002/rcm.7857

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Wide target analysis of acylglycerols in miso (Japanese fermented soybean paste) by supercritical fluid chromatography coupled with triple quadrupole mass spectrometry and the analysis of the correlation between taste and both acylglycerols and free fatty acids.2017

    • Author(s)
      Ogawa T, Izumi Y, Kusumoto K, Fukusaki E, Bamba T.
    • Journal Title

      Rapid Commun. Mass Spectrom.

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] メタボローム解析の現状と新規分析技術の開発.2016

    • Author(s)
      中谷航太,和泉自泰,福崎英一郎,馬場 健史.
    • Journal Title

      G.I.Research

      Volume: 24(4) Pages: 228-233

    • Related Report
      2016 Research-status Report
  • [Journal Article] 超臨界流体クロマトグラフィー/質量分析を用いたメタボリックプロファイリング.2016

    • Author(s)
      高橋政友,和泉自泰,馬場 健史.
    • Journal Title

      日本農薬学会誌

      Volume: 41(2) Pages: 260-266

    • NAID

      130005401987

    • Related Report
      2016 Research-status Report
  • [Journal Article] 超臨界流体クロマトグラフィーを用いた代謝物プロファイリング技術の開発と応用.2016

    • Author(s)
      竹田浩章,和泉自泰,馬場 健史.
    • Journal Title

      生物工学会誌

      Volume: 94(7) Pages: 405-408

    • Related Report
      2016 Research-status Report
  • [Journal Article] Lipidomic analysis of plasma lipoprotein fractions in myocardial infraction-prone rabbits2015

    • Author(s)
      Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Takayuki Yamada, Masaru Yoshida, Masashi Shiomi, Eiichiro Fukusaki, Takeshi Bamba
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 印刷中 Issue: 4 Pages: 476-482

    • DOI

      10.1016/j.jbiosc.2015.02.015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] MRM-DIFF: Data Processing Strategy for Differential Analysis in Large Scale MRM-based Lipidomics Studies.2015

    • Author(s)
      Tsugawa H, Ohta E, Izumi Y, Ogiwara A, Yukihira D, Bamba T, Fukusaki E, Arita M.
    • Journal Title

      Frontiers in Genetics.

      Volume: 5 Pages: 471-471

    • DOI

      10.3389/fgene.2014.00471

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High-throughput simultaneous analysis of pesticides by supercritical fluid chromatography coupled to high-resolution mass spectrometry.2015

    • Author(s)
      Ishibashi M, Izumi Y, Sakai M, Ando T, Fukusaki E, Bamba T.
    • Journal Title

      J. Agric. food Chem.

      Volume: 63(18) Issue: 18 Pages: 4457-4463

    • DOI

      10.1021/jf5056248

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 超臨界流体テクノロジーのフードメタボロミクスへの応用2015

    • Author(s)
      高橋政友,和泉自泰,馬場 健史
    • Journal Title

      バイオインダストリー

      Volume: 32(10) Pages: 17-24

    • Related Report
      2015 Research-status Report
  • [Presentation] 次世代メタボロミクスの技術開発と医学応用2017

    • Author(s)
      ○和泉 自泰
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台国際センター・東北大学(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] C型レクチンMincleによる死細胞由来糖脂質の認識2017

    • Author(s)
      ○永田 雅大1, 和泉 自泰2, 石川 絵里1, 宮本 智文3, 馬場 健史2, 山崎晶1
    • Organizer
      細胞競合・ダイイングコード合同若手ワークショップ
    • Place of Presentation
      ホテルコスモスクエア国際交流センター(大阪府大阪市)
    • Year and Date
      2017-01-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 分離モード並列化による親水性代謝物の包括的メタボローム分析2017

    • Author(s)
      和泉 自泰1, 鈴木 隆弘2, 高橋 政友1, 中谷 航太1, 押川 清孝1, 木村 元一2, 高原 健太郎2, 松本 雅記1, 馬場 健史1
    • Organizer
      第65回 質量分析総合討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Comprehensive Analysis of Hydrophilic Metabolites by Coupling Ion Chromatography and PFPP-based Liquid Chromatography Methods to High Resolution Mass Spectrometry2017

    • Author(s)
      Yoshihiro Izumi1, Takahiro Suzuki2, Masatomo Takahashi1, Kohta Nakatani1, Kiyotaka Oshikawa1, Motokazu Kimura2, Takahara Kentaro2, Masaki Matsumoto1, Takeshi Bamba
    • Organizer
      65th ASMS Conference on Mass Spectrometry and Allied Topics
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of retention behavior and separation of pesticides in reversed phase packed column SFC2017

    • Author(s)
      Yoshihiro Izumi, Motonao Nakao, Masatomo Takahashi, Takeshi Bamba
    • Organizer
      SFC Asia 2017, 11th International Conference on Packed-Column SFC
    • Related Report
      2017 Annual Research Report
  • [Presentation] 1細胞メタボロミクスに向けた基盤技術開発2017

    • Author(s)
      和泉 自泰1, 原 健士1, 中谷 航太1, 秦 康祐1, 山村 昌平2, 松本 雅記1, 馬場 健史1
    • Organizer
      第69回日本生物工学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] メタボロミクスとマトリックス効果2017

    • Author(s)
      和泉 自泰
    • Organizer
      第9回LC/MSワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 超臨界流体クロマトグラフィー三連四重極型質量分析によるワイドターゲット定量リピドミクス分析法の開発2017

    • Author(s)
      和泉 自泰1,竹田 浩章1,高橋 政友1,Thanai Paxton 2,加藤 紀子2,堀江 真之介2,長瀬 勝敏2,馬場 健史
    • Organizer
      第11回メタボロームシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] イオンクロマトグラフィー高分解能質量分析による動物培養細胞のメタボローム解析2017

    • Author(s)
      和泉 自泰1,高橋 政友1,鈴木 隆弘2,押川 清孝1,秦 康祐1,中谷 航太1,
    • Organizer
      第11回メタボロームシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 次世代メタボローム解析に向けた新たなクロマトグラフィー質量分析技術の開発2017

    • Author(s)
      和泉 自泰,馬場 健史
    • Organizer
      第28回クロマトグラフィー科学会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] ライフ分野におけるLC/MS/MSの活用法 ~メタボロミクス~2017

    • Author(s)
      ○和泉 自泰
    • Organizer
      鹿児島大学医学部ライフセミナー
    • Place of Presentation
      鹿児島大学 医学部(鹿児島県鹿児島市)
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] オミクス解析に基づく血中リポタンパク質脂質解析法の開発2017

    • Author(s)
      ○竹田 浩章1, 和泉 自泰1, Thanai Paxton2, 加藤 紀子2, 堀江 真之介2, 長瀬 勝敏2, 小池 智也3, 塩見 雅志3, 松田 史生4, 福崎 英一郎5, 馬場 健史1
    • Organizer
      第7回 学際的脂質創生研究部会講演会
    • Place of Presentation
      九州大学西新プラザ(福岡県福岡市)
    • Related Report
      2016 Research-status Report
  • [Presentation] DEVELOPMENT OF A HIGHLY SENSITIVE ANALYTICAL SYSTEM USING NANO LC/MS/MS TOWARD SINGLE CELL METABOLOMICS2016

    • Author(s)
      ○Kohta Nakatani1,2, Yoshihiro Izumi1,2, Takeshi Bamba1,2
    • Organizer
      International Conference on Single cell Research 2016
    • Place of Presentation
      Ito International Research Center, The University of Tokyo (Tokyo, Japan)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] SFC-QqQMSを用いたワイドターゲット定量リピドーム解析2016

    • Author(s)
      竹田 浩章1,和泉 自泰1,Thanai Paxton2,加藤 紀子2,堀江 真之介2,長瀬 勝敏2,○馬場 健史1
    • Organizer
      第10回 メタボロームシンポジウム
    • Place of Presentation
      鶴岡メタボロームキャンパス レクチャーホール(山形県鶴岡市)
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 超臨界流体クロマトグラフィー三連四重極型質量分析によるワイドターゲット定量リピドミクス分析手法の開発2016

    • Author(s)
      ○和泉 自泰
    • Organizer
      Waters MSフォーラム2016
    • Place of Presentation
      メルパルク大阪(大阪)、東京コンファレンスセンター・有明(東京)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Wide-targeted and quantitative lipidome analysis by supercritical fluid chromatography coupled with fast-scanning triple quadrupole mass spectrometry2016

    • Author(s)
      Hiroaki Takeda1, Yoshihiro Izumi1, Thanai Paxton2, Noriko Kato2, Shinnosuke Horie2, Katsutoshi Nagase2, ○Takeshi Bamba1
    • Organizer
      SFC 2016, 10th International Conference on Packed-Column SFC
    • Place of Presentation
      Melia’ Vienna hotel (ienna, Austria)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] イオンクロマトグラフィー高分解能質量分析による陰イオン性代謝物分析手法の開発2016

    • Author(s)
      和泉 自泰1, 高橋 政友1, 鈴木 隆弘2, 押川 清孝1, 木村 元一2, 坂本 茂2, 松本 雅記1, ○馬場 健史1
    • Organizer
      第68回 日本生物工学会大会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
  • [Presentation] ○和泉 自泰2016

    • Author(s)
      メタボロミクスの技術開発と医学応用
    • Organizer
      沖縄質量分析セミナー
    • Place of Presentation
      沖縄科学技術大学院大学、琉球大学医学研究科及び琉球大学機器分析支援センター(沖縄県)
    • Year and Date
      2016-08-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] イオンクロマトグラフィー高分解能質量分析による高精度メタボローム解析システムの開発2016

    • Author(s)
      ○和泉 自泰
    • Organizer
      Thermo SCIENTIFIC質量分析フォーラム2016
    • Place of Presentation
      ザ・リッツ・カールトン大阪(大阪)、東京コンファレンスセンター品川(東京)
    • Year and Date
      2016-08-02
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Widely Targeted Analysis of Hydrophilic Anionic Metabolites in Mammalian Cells by Ion Chromatography Coupled with High Resolution Mass Spectrometry2016

    • Author(s)
      ○Yoshihiro Izumi1, Takahiro Suzuki2, Motokazu Kimura2, Shigeru Sakamoto2,Takeshi Bamba1
    • Organizer
      64th ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Henry B. González Convention Center (San Antonio, TX, USA)
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a Wide-Targeted Quantitative Lipidomics Methodology by Supercritical Fluid Chromatography Coupled with Fast-Scanning Triple Quadrupole Mass Spectrometry2016

    • Author(s)
      ○Hiroaki Takeda1, Yoshihiro Izumi1, Thanai Paxton2, Noriko Kato2, Shinnosuke Horie2, Katsutoshi Nagase2, Takeshi Bamba1
    • Organizer
      64th ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Henry B. González Convention Center (San Antonio, TX, USA)
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 次世代メタボロミクスの技術開発と応用2016

    • Author(s)
      ○和泉 自泰
    • Organizer
      第76回 分析化学討論会
    • Place of Presentation
      岐阜薬科大学・岐阜大学(岐阜県岐阜市)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 超臨界流体クロマトグラフィー三連四重極型質量分析によるワイドターゲット定量リピドミクス手法の開発2016

    • Author(s)
      ○竹田 浩章1, 和泉 自泰1, Paxton, Thanai2, 加藤 紀子2, 堀江 真之介2, 長瀬 勝敏2, 馬場 健史1
    • Organizer
      第64回 質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府吹田市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] ワイドターゲットメタボローム分析による酵母システイン代謝推定生合成遺伝子の機能解析2016

    • Author(s)
      ○中谷 航太1, 和泉 自泰1,2, 馬場 健史1,2, Soontorngun, Nitnipa3, 向由起夫4, 福崎英一郎1
    • Organizer
      第64回 質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府吹田市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] イオンクロマトグラフィー高分解能質量分析による陰イオン性代謝物プロファイリング手法の開発2016

    • Author(s)
      ○和泉 自泰1, 鈴木 隆弘2, 木村 元一2, 坂本 茂2, 馬場 健史1
    • Organizer
      第64回 質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪府吹田市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
  • [Presentation] TCA回路酵素遺伝子過剰発現による Mortierella alpina の脂質生産性向上の検討2016

    • Author(s)
      島田良美, 安藤晃規, 和泉自泰, 馬場健史, 岸野重信, 櫻谷英治, 島純, 小川順
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター, 北海道札幌市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Highly-sensitive, accurate, and rapid measurement of low molecular weight compounds by utilizing supercritical fluid extraction and separation technologies2016

    • Author(s)
      Izumi, Y.
    • Organizer
      2016 The 5th Shimadzu International Collaborative Laboratory Forum
    • Place of Presentation
      Grand Hyatt Taipei Hotel, Taipei, Taiwan.
    • Year and Date
      2016-03-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 次世代メタボロミクス解析手法の開発と応用2016

    • Author(s)
      和泉自泰
    • Organizer
      第2回メタボロミクスミニシンポジウム
    • Place of Presentation
      大分大学医学部医学系研究科, 大分県由布市
    • Year and Date
      2016-02-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Supercritical fluid chromatography triple-quadrupole mass spectrometry-based methodology for highly-sensitive and high-throughput analysis of multiresidue pesticides2015

    • Author(s)
      Izumi, Y., Fukusaki, E., Bamba, T.
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii Convention Center etc, Honolulu, Hawaii, USA.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Lipidome analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits2015

    • Author(s)
      Takeda, H., Koike, T., Izumi, Y., Yamada, T., Yoshida, M., Shiomi, M., Fukusaki, E., Bamba, T.
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii Convention Center etc, Honolulu, Hawaii, USA.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rapid in-depth regioisomer focused lysophospholipidomics of human serum by online supercritical fluid extraction-supercritical fluid chromatography tandem mass spectrometry2015

    • Author(s)
      Izumi,Y., Nakao, M., Tuckett, N., Funada, Y., Uchikata, T., Iwata, Y., Tomita, M., Nishimura , M., Kim Ekroos., Bamba, T.
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii Convention Center etc, Honolulu, Hawaii, USA.
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 油糧糸状菌 Mortierella alpina のメタボローム解析2015

    • Author(s)
      和泉自泰, 安藤晃規, 阪本鷹行, 光永均, 中尾素直, 岸野重信, 福﨑英一郎, 櫻谷英治, 島純, 小川順, 馬場健史
    • Organizer
      第67回 日本生物工学会大会
    • Place of Presentation
      城山観光ホテル, 鹿児島県鹿児島市
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 超臨界流体クロマトグラフィー三連四重極型質量分析による残留農薬の高感度迅速一斉分析法の開発2015

    • Author(s)
      和泉自泰, 中尾素直, 福﨑英一郎, 馬場健史
    • Organizer
      第67回 日本生物工学会大会
    • Place of Presentation
      城山観光ホテル, 鹿児島県鹿児島市
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 残留農薬分析に資する新規スプリット方式オンライン超臨界流体抽出クロマトグラフシステムの開発2015

    • Author(s)
      酒井美穂, 安部秋晴, 市来弥生, 寺田英敏, 服部考成, 舟田康裕, 和泉自泰, 安藤孝, 福﨑英一郎, 馬場健史
    • Organizer
      第67回 日本生物工学会大会
    • Place of Presentation
      城山観光ホテル, 鹿児島県鹿児島市
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] SFC/MSのメタボロミクスへの応用2015

    • Author(s)
      和泉自泰
    • Organizer
      第2回メタボロームシンポジウム若手会
    • Place of Presentation
      ラフォーレ修善寺, 静岡県伊豆市
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] イオンクロマトグラフィー高分解能質量分析による新規メタボローム解析システムの開発2015

    • Author(s)
      和泉自泰, 馬場健史
    • Organizer
      Thermo SCIENTIFICイオンクロマトグラフセミナー, 無機イオン~有機酸イオンとメタボライトの分析 最新のテクノロジーと応用例
    • Place of Presentation
      千里ライフサイエンスセンター, 大阪
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] オンライン超臨界流体抽出-超臨界流体クロマトグラフィー質量分析を用いた血中脂溶性ビタミン類の高感度分析手法の開発2015

    • Author(s)
      上野真菜子, 和泉自泰, 舟田康裕, 岩田庸助, 冨田眞巳, 福崎英一郎, 馬場健史
    • Organizer
      第9回メタボロームシンポジウム
    • Place of Presentation
      三島市民文化会館 ゆうゆうホール 三島商工会議所, 静岡県三島市
    • Year and Date
      2015-09-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 心筋梗塞自然発症モデルウサギにおける血漿リポタンパク質粒子のリピドーム解析法の開発2015

    • Author(s)
      竹田浩章, 和泉自泰, 富田淳美, 小池智也, 塩見雅志, 松田史生, 福崎英一郎, 馬場健史
    • Organizer
      第9回メタボロームシンポジウム
    • Place of Presentation
      三島市民文化会館 ゆうゆうホール 三島商工会議所, 静岡県三島市
    • Year and Date
      2015-09-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 油糧微生物 Mortierella alpine のメタボローム解析2015

    • Author(s)
      和泉自泰, 安藤晃規, 阪本鷹行, 光永均, 中尾素直, 岸野重信, 福崎英一郎, 櫻谷英治, 島純,小川順, 馬場健史
    • Organizer
      第9回メタボロームシンポジウム
    • Place of Presentation
      三島市民文化会館 ゆうゆうホール 三島商工会議所, 静岡県三島市
    • Year and Date
      2015-09-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 超臨界流体クロマトグラフィーにおける脂質分子種の保持時間予測に基づくワイドターゲットリピドミクスシステムの開発2015

    • Author(s)
      山田貴之, 和泉自泰, 津川裕司, 福崎英一郎, 馬場健史
    • Organizer
      第9回メタボロームシンポジウム
    • Place of Presentation
      三島市民文化会館 ゆうゆうホール 三島商工会議所, 静岡県三島市
    • Year and Date
      2015-09-30
    • Related Report
      2015 Research-status Report
  • [Presentation] イオンクロマトグラフィー高分解能質量分析による新規メタボローム解析システムの開発2015

    • Author(s)
      和泉自泰, 馬場健史
    • Organizer
      Thermo SCIENTIFICイオンクロマトグラフセミナー, 無機イオン~有機酸イオンとメタボライトの分析 最新のテクノロジーと応用例
    • Place of Presentation
      コングレスクエア日本橋, 東京
    • Year and Date
      2015-09-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Fully automated on-line sample extraction and analysis of residual pesticides in agricultural products by using on-line SFE-SFC-MS2015

    • Author(s)
      Hattori, T., Uchikata, T., Terada, H., Ichikawa, C., Funada, Y., Ichiki, Y., Sakai, M., Ando, T., Izumi, Y., Fukusaki, E., Bamba, T.
    • Organizer
      RSC Tokyo International Conference 2015
    • Place of Presentation
      Makuhari Messe, Chiba-city, Japan.
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Automatically extraction and analysis using on-line supercritical fluid extraction (SFE) / supercritical fluid chromatography (SFC) system2015

    • Author(s)
      Uchikata, T., Terada, H., Funada, Y., Izumi, Y., Bamba, T.
    • Organizer
      SFC 2015, 9th International Conference on Packed-Column SFC
    • Place of Presentation
      Loews Philadelphia, Philadelphia, Pennsylvania, USA.
    • Year and Date
      2015-07-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Supercritical fluid chromatography tandem mass spectrometry: An alternative to LC/MS/MS for high-sensitivity and -throughput analysis of multiresidue pesticides2015

    • Author(s)
      Izumi, Y., Fukusaki, E., Bamba, T.
    • Organizer
      SFC 2015, 9th International Conference on Packed-Column SFC
    • Place of Presentation
      Loews Philadelphia, Philadelphia, Pennsylvania, USA.
    • Year and Date
      2015-07-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of an online supercritical fluid extraction-supercritical fluid chromatography/mass spectrometry method for the simultaneous and rapid analysis of fat-soluble vitamins2015

    • Author(s)
      Ueno, M., Izumi, Y., Funada, Y., Iwata, Y., Tomita, M., Fukusaki, E., Bamba, T.
    • Organizer
      SFC 2015, 9th International Conference on Packed-Column SFC
    • Place of Presentation
      Loews Philadelphia, Philadelphia, Pennsylvania, USA.
    • Year and Date
      2015-07-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fully automated on-line sample extraction and analysis of residual pesticides in agricultural products by using on-line SFE-SFC-MS2015

    • Author(s)
      Hattori, T., Uchikata, T., Terada, H., Ichikawa, C., Funada, Y., Ichiki, Y., Sakai, M., Ando, T., Izumi, Y., Fukusaki, E., Bamba, T
    • Organizer
      SFC 2015, 9th International Conference on Packed-Column SFC
    • Place of Presentation
      Loews Philadelphia, Philadelphia, Pennsylvania, USA.
    • Year and Date
      2015-07-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lipidomics of plasma lipoprotein fractions in myocardial infarction-prone rabbits2015

    • Author(s)
      Takeda, H., Koike, T., Izumi, Y., Yamada, T., Yoshida, M., Shiomi, M., Fukusaki, E., Bamba, T.
    • Organizer
      11th International Conference of the Metabolomics Society (Metabolomics2015)
    • Place of Presentation
      Hyatt Regency San Francisco Airport, San Francisco Bay Area, California, USA.
    • Year and Date
      2015-06-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心筋梗塞自然発症モデルウサギにおける血漿リポプロテイン画分のリピドーム解析2015

    • Author(s)
      竹田浩章, 小池智也, 和泉自泰, 山田貴之, 吉田優, 塩見雅志, 福崎英一郎, 馬場健史
    • Organizer
      第63回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場, 茨城県つくば市
    • Year and Date
      2015-06-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 超臨界流体クロマトグラフィータンデム質量分析による残留農薬の高感度迅速一斉分析法の開発2015

    • Author(s)
      和泉自泰, 福崎英一郎, 馬場健史
    • Organizer
      第63回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場, 茨城県つくば市
    • Year and Date
      2015-06-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Fully Automated On-Line Sample Extraction and Analysis of Residual Pesticides in Agricultural Products by using On-Line SFE-SFC-MS2015

    • Author(s)
      Hattori, T., Uchikata, T., Terada, H., Ichikawa, C., Funada, Y., Ichiki, Y., Sakai, M., Ando, T., Izumi, Y., Fukusaki, E., Bamba, T.
    • Organizer
      63rd ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      America's Convention Center, St. Louis, Missouri, USA.
    • Year and Date
      2015-05-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rapid In-Depth Regioisomer Focused Lysophospholipidomics of Human Serum by Online Supercritical Fluid Extraction-Supercritical Fluid Chromatography Tandem Mass Spectrometry2015

    • Author(s)
      Izumi,Y., Funada, Y., Uchikata, T., Iwata, Y., Tomita, M., Nishimura, M., Kim Ekroos., Bamba, T.
    • Organizer
      63rd ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      America's Convention Center, St. Louis, Missouri, USA.
    • Year and Date
      2015-05-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Supercritical fluid chromatography triple-quadrupole mass spectrometry: An alternative to LC/MS/MS for high-sensitivity and -throughput analysis of multiresidue pesticides2015

    • Author(s)
      Izumi,Y., Fukusaki, E., Bamba, T.
    • Organizer
      63rd ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      America's Convention Center, St. Louis, Missouri, USA.
    • Year and Date
      2015-05-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Supercritical Fluid. In “Encyclopedia of Lipidomics”2017

    • Author(s)
      Izumi Y, Takeda H, Bamba T.
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Book] Supercritical Fluid Extraction: Modifier. In “Encyclopedia of Lipidomics”2017

    • Author(s)
      Takeda H, Izumi Y, Bamba T.
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Book] Supercritical Fluid Extraction: Carbon Dioxide. In “Encyclopedia of Lipidomics”2017

    • Author(s)
      Takeda H, Izumi Y, Bamba T.
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Book] ヘルスケアを支えるバイオ計測2016

    • Author(s)
      和泉自泰, 竹田浩章, 馬場健史 (分担執筆)
    • Total Pages
      6
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Research-status Report
  • [Remarks] 九州大学生体防御医学研究所馬場研究室HP

    • URL

      http://bamba-lab.com/?lang=ja

    • Related Report
      2017 Annual Research Report
  • [Remarks] 九州大学研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K005704/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 九州大学研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K005704/research.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 九州大学馬場研究室HP

    • URL

      http://bamba-lab.com

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 識代謝物の製造方法、代謝物の定量方法、及び標識代謝物製造キット2017

    • Inventor(s)
      寺内勉,脇村明夏里,馬場健史,和泉自泰,相馬悠希
    • Industrial Property Rights Holder
      寺内勉,脇村明夏里,馬場健史,和泉自泰,相馬悠希
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-143639
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi