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Identification and reconstruction of a modular locomotor network in the mammalian spinal cord

Research Project

Project/Area Number 15K06695
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionUniversity of Toyama

Principal Investigator

Nishimaru Hiroshi  富山大学, 大学院医学薬学研究部(医学), 准教授 (20302408)

Co-Investigator(Renkei-kenkyūsha) KOBAYASHI RYOTA  国立情報学研究所, 情報学プリンシプル研究系, 助教 (70549237)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脊髄 / 歩行 / マウス / 歩行運動 / 運動ニューロン / リズム形成回路 / 神経回路
Outline of Final Research Achievements

In this study, we analyzed the output pattern of rhythmic motor activity in the left and right sides of a single segment preparation taken from the spinal cord of neonatal mice. Rhythm activity with patterns similar to actual walking can be induced in the motor neuron group in such preparation suggesting that a modular network that forms the rhythm is localized in a single segment. We estimated the average variations in excitatory and inhibitory synaptic conductance during a locomotion cycle from a single voltage trace. We found that the peak of excitatory conductance occurred during the active phase of the locomotor cycle, while the peak of inhibitory conductance occurred during the non-active phase. These results suggest that the locomotor-like activity is generated by push-pull modulation via excitatory and inhibitory synaptic inputs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] A single spike deteriorates synaptic conductance estimation2017

    • Author(s)
      Kobayashi Ryota、Nishimaru Hiroshi、Nishijo Hisao、Lansky Petr
    • Journal Title

      Biosystems

      Volume: 161 Pages: 41-45

    • DOI

      10.1016/j.biosystems.2017.07.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of excitatory and inhibitory synaptic conductance variations in motoneurons during locomotor-like rhythmic activity2016

    • Author(s)
      Kobayashi R, Nishimaru H, Nishijo H
    • Journal Title

      Neuroscience

      Volume: 335 Pages: 72-81

    • DOI

      10.1016/j.neuroscience.2016.08.027

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Differences in the spatial pattern of the rhythmic motor activity between th e thoracic and lumbar segmental networks in the a-chimaerin knockout m ouse spinal cord.2016

    • Author(s)
      Hiroshi Nishimaru, Kenta Inoue, Jumpei Matsumoto, Shigeyoshi Itohara, Takuji Iwasato, Hisao Nishijo
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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